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CAS No.: 6205-14-7

Hydroxycitric Acid Catalog No. CSN12153

Synonyms: HCA;羟基柠檬酸

Hydroxycitric acid, a natural product isolated and purified from the fruits of Garcinia atroviridis, can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis, and ameliorate high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects.

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描述Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase^[3]. Hydroxycitric Acid ((-)-Hydroxycitric acid (HCA)) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity^[4]. (-)-hydroxycitric acid (HCA) inhibits the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA^[5]. HCA treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There was significantly less calcium oxalate crystal deposition in mice treated with HCA. Calcium oxalate crystals induced the production of reactive oxygen species and reduced the activity of antioxidant defense enzymes. HCA attenuated oxidative stress induced by calcium oxalate crystallization. HCA had inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1β, and IL-6. In addition, HCA alleviated tubular injury and apoptosis caused by calcium oxalate crystals^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00699413	Obesity Diabe... more >>tes Mellitus, Type 2 Collapse <<	Phase 4	Terminated(Sponsor decided to ... more >>withdraw from study.) Collapse <<	-	United States, California ... more >> USC - Preventive Medicine Los Angeles, California, United States, 90033 Collapse <<
NCT00699413	-	-	Terminated(Sponsor decided to ... more >>withdraw from study.) Collapse <<	-	-
NCT01238887	Obesity Oxida... more >>tive Stress Collapse <<	Phase 1 Phase 2	Terminated(Some capsules used ... more >>in this study were been found to be cracked and leaking.) Collapse <<	-	United States, Florida ... more >> University of Florida General Clinical Research Center (GCRC) Gainesville, Florida, United States, 32608 Collapse <<

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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.8049 mL
- 24.0243 mL
- 48.0485 mL
- 5 mM
- 0.9610 mL
- 4.8049 mL
- 9.6097 mL
- 10 mM
- 0.4805 mL
- 2.4024 mL
- 4.8049 mL

技术信息

CAS号	6205-14-7	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C6H8O8	运输	蓝冰
分子量	208.12	别名	HCA;羟基柠檬酸

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