生物活性

• 描述IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02348190	Other Fatty Acid Oxidation Dis... more >>orders Diabetes Mellitus Insulin Resistance Collapse <<	Not Applicable	Completed	-	United States, Pennsylvania ... more >> Temple University Hospital Philadelphia, Pennsylvania, United States, 19140 Collapse <<
  NCT03563677	Rare Diseases ... more >> Orphan Diseases Collapse <<	Not Applicable	Recruiting	September 30, 2021	Germany ... more >> Center for Rare Diseases ZESE, University Hospital Recruiting Würzburg, Bavaria, Germany, 97080 Contact: Helge Hebestreit, MD    +49 931 201 27889    hebestreit@uni-wuerzburg.de    Contact: Stefanie Draxler    +49931 201 27729    draxler_s@ukw.de    Center for Rare Diseases ZSEA, University Hospital Recruiting Aachen, Germany, 52074 Contact: Christopher Schippers, Dr.    +49 241 80 85651    ZSEA@ukaachen.de    Center for Rare Diseases CeSER, St. Josef Hospital Recruiting Bochum, Germany, 44791 Contact: Marion Morzuch    + 49 234 509 2601    info@ceser.de    Center for Rare Diseases FRZSE, UNiversity Hospital Not yet recruiting Frankfurt, Germany, 60590 Contact: Thomas OF Wagner, Prof. Dr.    +49 69 6301 84318    FRZSE@kgu.de    Center for Rare Diseases, Hannover Medical School Recruiting Hannover, Germany, 30625 Contact: Cornelia Zeidler    +49 511 557105    Zeidler.Cornelia@mh-hannover.de    Center for Rare Diseases MKSE, Otto von Guericke University Recruiting Magdeburg, Germany Contact: Klaus Mohnike, Prof. Dr.    +49 345 1325 9595    sesa@med.ovgu.de    Center for Rare Diseases, Medical Center Not yet recruiting Mainz, Germany, 55131 Contact: Oliver Tüscher, Prof. Dr.    +49 6131 17 2596    tuescher@uni-mainz.de    Center for Rare Diseases, University Hospital Recruiting Muenster, Germany, 48149 Contact: Frank Rutsch, Prof. Dr.    +49 2 51 83 47 700    frank.rutsch@ukmuenster.de    Center for Rare Diseases ZSER, University Hospital Not yet recruiting Regensburg, Germany, 93053 Contact: Mark Berneburg, Prof. Dr.    +49 941 944-9696    zser@ukr.de    Center for Rare Diseases, University Hospital Not yet recruiting Tuebingen, Germany, 72076 Contact: Jutta Eymann    +49 7071 29 85170    lotsin@zse-tuebingen.de    Center for Rare Diseases, University Hospital Recruiting Ulm, Germany, 89075 Contact: Bettina Hilbig    +49 731 500-57080    zse@uniklinik-ulm.de Collapse <<

• 参考文献

• [1] Shu Y, Liu Y, et al. Aspirin-Triggered Resolvin D1 Inhibits TGF-β1-Induced EndMT through Increasing the Expression of Smad7 and Is Closely Related to Oxidative Stress. Biomol Ther (Seoul). 2016 Mar 1;24(2):132-9.

  [2] Waelchli R, Bollbuck B, et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12.