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CAS No.: 20784-50-3

Isobavachalcone/异补骨脂查尔酮 Catalog No. CSN13965

Synonyms: Corylifolinin;Isobacachalcone;IBC

Isobavachalcone can induce apoptosis in neuroblastoma, is a chalcone isolated and purified from Angelica keiskei and the fruits of Psoralea corylifolia L.

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生物活性

描述Isobavachalcone (IBC) is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibited cancer anti-promotive and anti-proliferative activity^[3]. Isobavachalcone inhibited massive granulomas, decreased inflammatory cells infiltration and oxidative stress markers level, but it can increase antioxidant enzymes level. Isobavachalcone decreased TNF-α production in BALF and lung tissue. Isobavachalcone can inhibit NF-κB pathway that may be mediated by upregulation of A20. Isobavachalcone can activate NRF2/HO-1 pathway and inhibit adhesion molecule expression^[4]. IBC is able to significantly inhibit proliferation and induce apoptosis of Tca8113 (tongue squamous cell carcinoma) cells in vitro. IBC treatment resulted in typical apoptotic morphology of nuclear fragmentation and apoptotic bodies in Tca8113 cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0829 mL
- 15.4145 mL
- 30.8290 mL
- 5 mM
- 0.6166 mL
- 3.0829 mL
- 6.1658 mL
- 10 mM
- 0.3083 mL
- 1.5414 mL
- 3.0829 mL

技术信息

CAS号

20784-50-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H20O4

运输

蓝冰

分子量

324.37

别名

Corylifolinin;Isobacachalcone;IBC;补骨脂乙素

溶解度

DMSO	62.0 mg/mL (191.1 mM)
Water	Insoluble
Ethanol	63.0 mg/mL (194.2 mM)

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Isobavachalcone/异补骨脂查尔酮 Catalog No. CSN13965

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