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CAS No.: 20175-84-2

Isodiospyrin/异柿醌 Catalog No. CSN15179

Synonyms: 异柿醌

Isodiospyrin, a natural product isolated and purified from the herbs of Diospyros morrisiana, exhibits remarkably good antifungal activity, the MIC values of the isodiospyrin was 5-160 μg/mL & the MFC values was 40-160 μg/mL.

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描述Isodiospyrin, a natural product isolated and purified from the herbs of Diospyros morrisiana, exhibits remarkably good antifungal activity, the MIC values of the isodiospyrin was 5-160 μg/mL & the MFC values was 40-160 μg/mL. Isodiospyrin has a broad spectrum of antibacterial activity. The MIC values of isodiospyrin against Gram-positive bacteria ranged from 0.78 to 50 mg/mL. While those against Pseudomonas aeruginosa ATCC 15443 and S. typhi ranged from 50 to 100 mg/mL.exhibits cytotoxic activity to tumor cell lines. It also inhibits hTOPO I by direct binding to htopo I, which limits hTOPO I access to the DNA substrate, and exhibits strong inhibitory effect on the kinase activity of htopo I toward splicing factor 2/alternate splicing factor in the absence of DNA.
参考文献

[1] Ting CY, Hsu CT, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 2003 Nov 15;66(10):1981-91.
[2] Adeniyi BA, Fong HH, et al. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae). Phytother Res. 2000 Mar;14(2):112-7.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6714 mL
- 13.3568 mL
- 26.7137 mL
- 5 mM
- 0.5343 mL
- 2.6714 mL
- 5.3427 mL
- 10 mM
- 0.2671 mL
- 1.3357 mL
- 2.6714 mL

技术信息

CAS号	20175-84-2	储存条件	粉末液体 -20°C:3-6 月 -80°C:12月
分子式	C22H14O6	运输	蓝冰
分子量	374.34	别名	异柿醌

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