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CAS No.: 17290-70-9

Isosinensetin/异橙黄酮 Catalog No. CSN13555

Synonyms: 6-Demethoxynobiletin;异橙黄酮

Isosinensetin exhibits HIV-1 protease inhibiting and antioxidant activities. It is a natural product isolated and purified from the fruit of Citrus aurantium L..

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400-920-2911

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技术信息

生物活性

描述Isosinensetin, a polymethoxylated flavone extracted from pericarpium citri reticulatae viride, exhibits inhibition on P-glycoprotein (P-gp) in MDR1-MDCKII cells^[3]. Isosinensetin, exhibited significant inhibition (>50 %) on OATP1B1 (Organic anion transporting polypeptide 1B1) in OATP1B1-HEK293 cells, which reduced the OATP1B1-mediated influx of methotrexate, accordingly decreased its cytotoxicity in OATP1B1-HEK293 cells and increased its AUC0-t in different extents in rats, from 28.27%-82.71 %. In bosentan-induced rat liver injury models, isosinensetin reduced the levels of serum total bile acid (TBA) and the liver concentration of bosentan in different degrees^[4].
参考文献

[1] Ye X, Song F, et al. [Simultaneous determination of 11 constituents in Citrus reticulate 'Chachi' by high performance liquid chromatography] . Se Pu. 2015 Apr;33(4):423-7. Chinese.
[2] Zhao BT, Kim EJ, et al. Quality evaluation and pattern recognition analyses of marker compounds from five medicinal drugs of Rutaceae family by HPLC/PDA. Arch Pharm Res. 2015 Aug;38(8):1512-20.
[3] Bai J, Zhao S, Fan X, et al. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicol Appl Pharmacol. 2019;369:49-59
[4] Fan X, Bai J, Hu M, et al. Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects. Toxicology. 2020;437:152445

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6855 mL
- 13.4276 mL
- 26.8551 mL
- 5 mM
- 0.5371 mL
- 2.6855 mL
- 5.3710 mL
- 10 mM
- 0.2686 mL
- 1.3428 mL
- 2.6855 mL

技术信息

CAS号	17290-70-9	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C20H20O7	运输	蓝冰
分子量	372.37	别名	6-Demethoxynobiletin;异橙黄酮

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