生物活性

• 描述Isotretinoin, an analogue of retinoic acid and an endogenous agonist for retinoic acid receptors, is a medication used for the treatment of severe acne, also used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01701479	Neuroblastoma	Phase 1 Phase 2	Unknown	December 2013	Austria ... more >> St. Anna Kinderspital Recruiting Vienna, Austria, 1090 Contact: Ruth Ladenstein, MD    +43(1)40470-4750    ruth.ladenstein@ccri.at    Principal Investigator: Ruth Ladenstein, MD          France Institut Curie Recruiting Paris, France, 75248 Contact: Jean Michon, MD    +33-1-44-35-4550    jean.michon@curie.net    Principal Investigator: Jean Michon, MD          Sub-Investigator: Daniel Orbach, MD          Institut Gustave Roussy Recruiting Villejuif, France, 94805 Contact: Dominique Valteau-Couanet, MD    +33-1-42114872    valteau@igr.fr    Principal Investigator: Dominique Valteau-Couanet, MD          Sub-Investigator: Angela Digiannatale, MD          Germany University Children's Hospital Recruiting Greifswald, Germany, 17475 Contact: Holger Lode, MD, PhD    +49 3834 866301    lode@uni-greifswald.de    Principal Investigator: Holger Lode, Md, Phd          Israel Schneider Children's Medical Centre of Israel Recruiting Petach Tikvah, Israel, 49202 Contact: Isaac Yaniv, MD    +972-3-9253669    iyaniv@clalit.org.it    Principal Investigator: Isaac Yaniv, MD          Sub-Investigator: Shifra Ash, MD          Italy Gaslini Children's Hospital Recruiting Genova, Italy, 16147 Contact: Alberto Garaventa, MD    +39-010-5636694-714    albertogaraventa@ospedale-gaslini.ge.it    Principal Investigator: Alberto Garaventa, MD          Sub-Investigator: Carla Manzitti, MD          Spain Hospital Universitario La Fe Recruiting Valencia, Spain, 46009 Contact: Victoria Castel, MD    +34-96-197-3304    castel_vic@gva.es    Principal Investigator: Victoria Castel, MD          Sub-Investigator: Adela Canete, MD          United Kingdom Birmingham Children's Hospital NHS Foundation Trust Not yet recruiting Birmingham, United Kingdom, B4 6NH Contact: Pamela Kearns, MBChB, MRCP (paeds), PhD    +44121 3338238    p.r.kearns@bham.ac.uk    Principal Investigator: Pamela Kearns, MBChB, MRCP (paeds), PhD          University Hospitals Bristol NHS Foundation Trust Not yet recruiting Bristol, United Kingdom, BS2 8BJ Contact: Helen Rees, MBBS, MRCP(Paeds), DCH    +44117 342 28815    Helen.rees@uhbristol.nhs.uk    Principal Investigator: Helen Rees, MBBS, MRCP(Paeds), DCH          Leeds Teaching Hospitals NHS Trust Not yet recruiting Leeds, United Kingdom, LS1 3EX Contact: Martin Elliott, MBChB, MRCP, PhD    +44113 3928039    Martin.elliott@leedsth.nhs.uk    Principal Investigator: Martin Elliott, MBChB, MRCP, PhD          Alder Hey Children's NHS Foundation Trust Not yet recruiting Liverpool, United Kingdom, L12 2AP Contact: Lisa Howell, B.Med.Sci, BmBs, MRCPCH    +441512525976    Lisa.howell@alderhey.nhs.uk    Principal Investigator: Lisa Howell, B.Med.Sci, BmBs, MRCPCH          University College Hospitals NHS Foundation Trust Not yet recruiting London, United Kingdom, NW1 2BU Contact: Ananth Shankar, DCH, MD, MRCP    +44845 1555000 ext 79490    ananth.shankar@uclh.nhs.uk    Principal Investigator: Ananth Shankar, DCH, MD, MRCP          Great Ormond Street Hospital for Children NHS Foundation Trust Not yet recruiting London, United Kingdom, WC1N 3JH Contact: John Anderson, MBBS, MRCP (Paeds), PhD    +442074059200 ext 8832    j.anderson@ich.ucl.ac.uk    Principal Investigator: John Anderson, MBBS, MRCP (Paeds), PhD          The Newcastle upon Tyne Hospitals NHS Foundation Trust Not yet recruiting Newcastle, United Kingdom, NE1 4LP Contact: Deborah Tweddle, MBChB (Hons), PhD, FRCPCH    +44191 2824068    deborah.tweddle@nuth.nhs.uk    Principal Investigator: Deborah Tweddle, MBChB (Hons), PhD, FRCPCH Collapse <<
  NCT00025038	Juvenile Myelomonocytic Leukem... more >>ia Collapse <<	Phase 2	Completed	-	United States, California ... more >> Children's Oncology Group Arcadia, California, United States, 91006-3776 Collapse <<
  NCT03042429	Neuroblastoma	Phase 3	Completed	-	Germany ... more >> University of Cologne Koln, Germany, 50924 Collapse <<

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• 参考文献

• [1] Smith-Thomas L, Lott I, Bronner-Fraser M. Effects of isotretinoin on the behavior of neural crest cells in vitro. Dev Biol. 1987 Sep;123(1):276-81.

  [2] Webster WS, Johnston MC, et al. Isotretinoin embryopathy and the cranial neural crest: an in vivo and in vitro study. J Craniofac Genet Dev Biol. 1986;6(3):211-22.