1043854-13-2|4-(((4-(4-(2-Chlorophenyl)piperazin-1-yl)-6-phenylpyrimidin-2-yl)thio)methyl)benzoic acid|CsnPharm

CAS No.: 1043854-13-2

J14 Catalog No. CSN24727

J14 is an ATP- competitive Srx inhibitor with IC50 value of 8.1μM. J14 leads to intracellular ROS accumulation and can selectively kill cancer cells through a ROS-mediated cell death mechanism.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Srx is an antioxidant peroxidase which is abundantly expressed in various cancers cells and allows cancer cells to overcome oxidative stress conditions. J14 is an ATP- competitive Srx inhibitor with IC50 value of 8.1μM. J14 leads to intracellular ROS accumulation and can selectively kill cancer cells through a ROS-mediated cell death mechanism. J14 treatment at concentration of 20μM significantly increased the accumulation of sulfinic Prxs and intracellular ROS, thus significantly induced cell death in A549 cells in a timedependent manner during 24-96h and resulted in approximately 40% cell death in 96h. Mitochondrial damage, cytochrome release, and caspase activation could be observed after J14 treatment. Administration of J14 at dose of 50mg/kg, i.p., daily, for 16 days reduced the growth of human lung tumor without acute toxicity in human lung cancer A549 xenograft model.
作用机制J14 binds to the ATP binding site, acting as a competitive inhibitor of ATP.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9341 mL
- 9.6704 mL
- 19.3408 mL
- 5 mM
- 0.3868 mL
- 1.9341 mL
- 3.8682 mL
- 10 mM
- 0.1934 mL
- 0.9670 mL
- 1.9341 mL

技术信息

CAS号

1043854-13-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H25ClN4O2S

运输

蓝冰

分子量

517.04

别名

溶解度

DMSO	170.0 mg/mL (328.8 mM)
Water	insoluble

动物实验配方

10%DMSO + 35%PEG400 + 10%tween80 + 45%Water

5 mg/mL

clear

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

J14 Catalog No. CSN24727

靶点选择性

请登录您的专属账户

确认信息