生物活性

• 靶点	K-Ras (G12C) EC50:0.32μM

• 描述K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02743923	Carcinoma, Non-Small Cell Lung	Phase 3	Recruiting	April 2020	Netherlands ... more >> VUmc Medical Center Recruiting Amsterdam, Noord-Holland, Netherlands, 1081HV Contact: Idris Bahce, MD       i.bahce@vumc.nl    Principal Investigator: Idris Bahce, MD          Medical spectrum Twente Recruiting Enschede, Overijssel, Netherlands, 7500 KA Contact: Hugo Schouwink, MD       J.Schouwink@mst.nl    Principal Investigator: Hugo Schouwink, MD          Meander Medical Center Recruiting Amersfoort, Utrecht, Netherlands, 3818 ES Contact: Joop van den Brand, MD       JJG.vanden.Brand@meandermc.nl    Principal Investigator: Joop van den Brand, MD          ZGT Recruiting Almelo, Netherlands, 7609 PP Contact: Jeske Staal, MD       j.staal@zgt.nl    Principal Investigator: Jeske Staal, MD          Antoni van Leeuwenhoek Recruiting Amsterdam, Netherlands, 1066CX Contact: Egbert Smit       e.smit@nki.nl    Principal Investigator: Egbert Smit, MD          OLVG Not yet recruiting Amsterdam, Netherlands, 1090 HM Contact: A Moons, MD       A.Moons-Pasic@olvg.nl    Principal Investigator: A Moons, MD          Gelre Ziekenhuis Recruiting Apeldoorn, Netherlands Contact: Niels Pronk, MD       n.pronk@gelre.nl    Principal Investigator: Niels Pronk, MD          Amphia Hospital Recruiting Breda, Netherlands Contact: Nicolaas van Walree, MD       nwalree@amphia.nl    Principal Investigator: Nicolaas van Walree, MD          Jeroen Bosch Hospital Recruiting Den Bosch, Netherlands Contact: Bonne Biesma, MD       b.biesma@jbz.nl    Principal Investigator: Bonne Biesma, MD          Haga Recruiting Den Haag, Netherlands, 2545 CH Contact: Pepijn Brocken, MD       p.brocken@hagaziekenhuis.nl    Principal Investigator: Pepijn Brocken, MD          Deventer Ziekenhuis Recruiting Deventer, Netherlands Contact: Suzy Samii, MD       s.samii@dz.nl    Principal Investigator: Suzy Samii, MD          Albert Schweitzer ziekenhuis Recruiting Dordrecht, Netherlands Contact: Eric van Thiel, MD       EricvanThiel@asz.nl    Principal Investigator: Eric van Thiel, MD          Ziekenhuis Gelderse Vallei Recruiting Ede, Netherlands Contact: Wouter de Jong, MD       jongw@zgv.nl    Principal Investigator: Wouter de Jong, MD          Maxima Medisch Centrum Recruiting Eindhoven, Netherlands, 5631 BM Contact: Arjen van Henten, MD       a.vanhenten@mmc.nl    Principal Investigator: Arjen van Henten, MD          Groene Hart Recruiting Gouda, Netherlands Contact: ten Heuvel, MD       alexandra.ten.heuvel@ghz.nl    Principal Investigator: ten Heuvel, MD          UMCG Recruiting Groningen, Netherlands, 9713 GZ Contact: Harry Groen, MD       h.j.m.groen@umcg.nl    Principal Investigator: Harry Groen, MD          Martini Ziekenhuis Recruiting Groningen, Netherlands Contact: John van Putten, MD       jwg.van.putten@mzh.nl    Principal Investigator: John van Putten, MD          Tergooi ziekenhuizen Recruiting Hilversum, Netherlands Contact: Jan Maarten van Haarst, MD       jvanhaarst@tergooi.nl    Principal Investigator: Jan Maarten van Haarst, MD          Spaarne Gasthuis Recruiting Hoofddorp, Netherlands, 2130 AT Contact: Frans Krouwels, MD       fkrouwels@spaarnegasthuis.nl    Principal Investigator: Frans Krouwels, MD          Medisch Centrum Leeuwarden Recruiting Leeuwarden, Netherlands Contact: Venmans, MD          Principal Investigator: Venmans, MD          Maastricht University Medical Center Recruiting Maastricht, Netherlands Contact: Anne-Marie Dingemans, MD       a.dingemans@mumc.nl    Principal Investigator: Anne-Marie Dingemans, MD          Maasstad ziekenhuis Recruiting Rotterdam, Netherlands, 3007 AC Contact: Susan van 't Westeinde, MD       westeindes@maasstadziekenhuis.nl    Contact: , MD          Principal Investigator: Susan van 't Westeinde, MD          St. Fransicus Gasthuis Recruiting Rotterdam, Netherlands, 3045 PM Contact: Wessel Hanselaar, MD       w.hanselaar@franciscus.nl    Principal Investigator: Wessel Hanselaar, MD          Medical Center Haaglanden Recruiting the Hague, Netherlands Contact: Klaar Maas, MD       k.maas@mchaaglanden.nl    Principal Investigator: Klaar Maas, MD          Diakonessenhuis Utrecht Recruiting Utrecht, Netherlands, 3582 KE Contact: Leontine van Elden, MD       lvelden@diakhuis.nl    Principal Investigator: Leontine van Elden, MD          St. Antonius ziekenhuis Recruiting Utrecht, Netherlands Contact: Franz Schramel, MD       f.schramel@antoniusziekenhuis.nl    Principal Investigator: Franz Schramel, MD          VieCuri Medisch Centrum voor Noord-Limburg Recruiting Venlo, Netherlands Contact: Vivian van Kampen, MD       vvankampen@viecuri.nl    Principal Investigator: Vivian van Kampen, MD          Isala Klinieken Recruiting Zwolle, Netherlands, 8000 GK Contact: Jos Stigt       j.a.stigt@isala.nl    Principal Investigator: Jos Stigt, MD Collapse <<
  NCT02642042	KRAS Gene Mutation ... more >> Recurrent Non-Small Cell Lung Carcinoma Stage IV Non-Small Cell Lung Cancer AJCC v7 Collapse <<	Phase 2	Active, not recruiting	October 15, 2020	-
  NCT03114319	Advanced EGFRmutant NonSmallSe... more >>llLungCancer (NSCLC),KRAS G12C NSCLC,CRC,Esophageal SquamousCellCancer (SCC),Head/Neck SCC,RAS/RAF Wild-type Other Solid Tumor Collapse <<	Phase 1	Recruiting	August 3, 2020	United States, Massachusetts ... more >> Novartis Investigative Site Recruiting Boston, Massachusetts, United States, 02215 Contact: Beth Meyers    617-643-1820    Betha_meyers@dfci.harvard.edu    Principal Investigator: Geoffrey Shapiro          United States, New York Novartis Investigative Site Recruiting New York, New York, United States, 10065 Contact: Murielle Georges    656-888-4563    georgesm@mskcc.org    Principal Investigator: Helena Yu          Canada, Ontario Novartis Investigative Site Recruiting Toronto, Ontario, Canada, M5G 1Z5 Japan Novartis Investigative Site Recruiting Kobe-shi, Hyogo, Japan, 650-0017 Netherlands Novartis Investigative Site Recruiting Rotterdam, Netherlands, 3075 EA Singapore Novartis Investigative Site Recruiting Singapore, Singapore, 169610 Spain Novartis Investigative Site Recruiting Barcelona, Catalunya, Spain, 08035 Collapse <<