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CAS No.: 1431985-92-0
K02288 is an inhibitor of type I BMP receptor. It targeting ALK2, ALK1 and ALK6 with IC50 of 1.1, 1.8, 6.4 nM, respectively.
生物活性
靶点 | ALK6 IC50:6.4nM | ALK1 IC50:1.8nM | ALK2 IC50:1.1nM |
实验方案
技术信息
CAS号 | 1431985-92-0 | 储存条件 |
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分子式 | C20H20N2O4 | 运输 | 蓝冰 | |||||||
分子量 | 352.38 | 别名 | ||||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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HEK293T cells | - | Function assay | 30 mins | Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assay, IC50=3.4 μM | 25101911 |
mouse C2C12 cells | - | Function assay | 30 mins | Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay, IC50=0.23 μM | 25101911 |
靶点 | Description | IC50 |
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ALK6 | IC50:6.4nM | |
ALK1 | IC50:1.8nM | |
ALK2 | IC50:1.1nM |
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