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CAS No.: 487-79-6

Synonyms: Digenin;Helminal;Digenic acid

Kainic acid is a selective agonist at kainate receptors. Potent excitant and neurotoxin.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS. Kainic acid is a potent neurotoxin, and induces selective neuronal loss in the rat hippocampus. Kainic acid acts on the kainate receptors, and kainic acid neurotoxicity may be in part mediated by oxidative stress^[3]. The neurotoxic properties of kainic acid and ibotenic acid following intrahippocampal injection in neonatal rats and found significant pyramidal cell death following injection of 1.0 microgram kainic acid in 6, 7 and 9-day-old pups. At doses 2.5 or five times this amount, significant pyramidal cell loss was obtained in 5-day-old rats as well^[4]. The systemic injection of a single low dose (7 mg/kg) of kainic acid to ovariectomized rats produced a marked loss of Nissl-stained and somatostatin-immunoreactive hilar neurons^[5]. The kainic acid-induced lesions potentiated the locomotor response to both the dopaminergic agonist, d-amphetamine, and the cholinergic antagonist, scopolamine, attenuated the cataleptic response to the dopaminergic antagonist, haloperidol, and potentiated the cataleptic acid and convulsive responses to the cholinergic agonist, pilocarpine^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02108015	Healthy Volunteers	Phase 1	Terminated	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT03244345	Depression and Epilepsy	Not Applicable	Recruiting	February 20, 2021	France ... more >> Assistance Publique Hôpitaux de Marseille Recruiting Marseille, France, 13354 Contact: Aïleen Mc Gonigal, MD aileen.mcgonigal@ap-hm.fr Chu Tours Not yet recruiting Tours, France Contact: Bertrand DE TOFFOL, MD/PhD bertrand.detoffol@univ-tours.fr Collapse <<

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技术信息

CAS号	487-79-6	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C10H15NO4	运输	蓝冰
分子量	213.23	别名	Digenin;Helminal;Digenic acid;红藻氨酸

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