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CAS No.: 587871-26-9
Synonyms: Ku-55933;ATM Kinase Inhibitor
KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
生物活性
实验方案
技术信息
CAS号 | 587871-26-9 | 储存条件 |
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分子式 | C21H17NO3S2 | 运输 | 蓝冰 | |||||||||||||
分子量 | 395.49 | 别名 | Ku-55933;ATM Kinase Inhibitor | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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639-V | - | Growth Inhibition Assay | - | IC50=27.5119 μM | SANGER |
697 | - | Growth Inhibition Assay | - | IC50=19.0201 μM | SANGER |
8305C | - | Growth Inhibition Assay | - | IC50=16.1889 μM | SANGER |
A101D | - | Growth Inhibition Assay | - | IC50=45.4456 μM | SANGER |
A2780 | - | Growth Inhibition Assay | - | IC50=27.641 μM | SANGER |
A29 MEF | 10 μM | Function Assay | 1h | blocks the phosphorylation of Akt at Ser473 | 20053781 |
A549 | - | Growth Inhibition Assay | - | IC50=43.931 μM | SANGER |
A549 | 10 μM | Function Assay | 1 h | suppresses Nano-Co-induced p53 accumulation | 22559321 |
A704 | - | Growth Inhibition Assay | - | IC50=19.8305 μM | SANGER |
BALL-1 | - | Growth Inhibition Assay | - | IC50=47.832 μM | SANGER |
BB30-HNC | - | Growth Inhibition Assay | - | IC50=49.9498 μM | SANGER |
BFTC-905 | - | Growth Inhibition Assay | - | IC50=25.5944 μM | SANGER |
BHT-101 | - | Growth Inhibition Assay | - | IC50=28.6572 μM | SANGER |
C32 | - | Growth Inhibition Assay | - | IC50=40.4024 μM | SANGER |
Ca9-22 | - | Growth Inhibition Assay | - | IC50=28.714 μM | SANGER |
CAL-12T | - | Growth Inhibition Assay | - | IC50=13.617 μM | SANGER |
CAL-33 | - | Growth Inhibition Assay | - | IC50=42.6749 μM | SANGER |
CAL-51 | - | Growth Inhibition Assay | - | IC50=40.0612 μM | SANGER |
CAL-72 | - | Growth Inhibition Assay | - | IC50=5.48084 μM | SANGER |
ChaGo-K-1 | - | Growth Inhibition Assay | - | IC50=16.6568 μM | SANGER |
CHL-1 | - | Growth Inhibition Assay | - | IC50=23.7292 μM | SANGER |
CHP-134 | - | Growth Inhibition Assay | - | IC50=42.8496 μM | SANGER |
COLO-684 | - | Growth Inhibition Assay | - | IC50=14.1569 μM | SANGER |
COLO-829 | - | Growth Inhibition Assay | - | IC50=38.4159 μM | SANGER |
CTB-1 | - | Growth Inhibition Assay | - | IC50=17.2259 μM | SANGER |
D-263MG | - | Growth Inhibition Assay | - | IC50=29.344 μM | SANGER |
D-283MED | - | Growth Inhibition Assay | - | IC50=20.5339 μM | SANGER |
D-423MG | - | Growth Inhibition Assay | - | IC50=15.5236 μM | SANGER |
D-566MG | - | Growth Inhibition Assay | - | IC50=49.9096 μM | SANGER |
DB | - | Growth Inhibition Assay | - | IC50=37.9185 μM | SANGER |
DBTRG-05MG | - | Growth Inhibition Assay | - | IC50=15.6111 μM | SANGER |
DEL | - | Growth Inhibition Assay | - | IC50=26.8356 μM | SANGER |
DMS-273 | - | Growth Inhibition Assay | - | IC50=44.7567 μM | SANGER |
DOK | - | Growth Inhibition Assay | - | IC50=15.3329 μM | SANGER |
DU-145 | - | Growth Inhibition Assay | - | IC50=3.27352 μM | SANGER |
EKVX | - | Growth Inhibition Assay | - | IC50=31.5847 μM | SANGER |
EM-2 | - | Growth Inhibition Assay | - | IC50=31.6304 μM | SANGER |
EPLC-272H | - | Growth Inhibition Assay | - | IC50=46.9503 μM | SANGER |
ES7 | - | Growth Inhibition Assay | - | IC50=11.788 μM | SANGER |
ES8 | - | Growth Inhibition Assay | - | IC50=34.8975 μM | SANGER |
EW-13 | - | Growth Inhibition Assay | - | IC50=27.4308 μM | SANGER |
FADU | - | Growth Inhibition Assay | - | IC50=41.2502 μM | SANGER |
G-361 | - | Growth Inhibition Assay | - | IC50=46.2138 μM | SANGER |
GCIY | - | Growth Inhibition Assay | - | IC50=16.7905 μM | SANGER |
GI-1 | - | Growth Inhibition Assay | - | IC50=25.7055 μM | SANGER |
GOTO | - | Growth Inhibition Assay | - | IC50=11.6996 μM | SANGER |
GT3TKB | - | Growth Inhibition Assay | - | IC50=26.5342 μM | SANGER |
HAL-01 | - | Growth Inhibition Assay | - | IC50=28.7615 μM | SANGER |
HCC1569 | - | Growth Inhibition Assay | - | IC50=28.4897 μM | SANGER |
HCC1806 | - | Growth Inhibition Assay | - | IC50=43.411 μM | SANGER |
HCC2157 | - | Growth Inhibition Assay | - | IC50=22.8054 μM | SANGER |
HCC2998 | - | Growth Inhibition Assay | - | IC50=17.6733 μM | SANGER |
HCC70 | - | Growth Inhibition Assay | - | IC50=19.489 μM | SANGER |
HDLM-2 | - | Growth Inhibition Assay | - | IC50=42.9084 μM | SANGER |
HeLa | 1-100μM | Growth Inhibition Assay | 24 h | inhibits the cell proliferation | 23185347 |
HepG2 | 10 μM | Growth Inhibition Assay | 24 h | blocks SC-III3-induced S phase arrest | 25527123 |
HepG2 | 10 μM | Function Assay | 24 h | suppresses the phosphorylations of ATM on Ser1981, Chk1 on Ser345, Chk2 on Thr68, and Cdk2 on Tyr15 induced by SC-III3 | 25527123 |
HH | - | Growth Inhibition Assay | - | IC50=8.27671 μM | SANGER |
HL-60 | 10 μM | Function Assay | 0.5 h | reduces phosphorylation of Chk2 | 23934411 |
HO-1-N-1 | - | Growth Inhibition Assay | - | IC50=48.9676 μM | SANGER |
HOP-92 | - | Growth Inhibition Assay | - | IC50=35.9277 μM | SANGER |
Hs-578-T | - | Growth Inhibition Assay | - | IC50=15.4182 μM | SANGER |
HSC-3 | - | Growth Inhibition Assay | - | IC50=21.1835 μM | SANGER |
HT-1376 | - | Growth Inhibition Assay | - | IC50=46.7426 μM | SANGER |
hTCEpi | 10 μM | Growth Inhibition Assay | - | prevents the cytopathic effect of HSV-1 | 24370835 |
HuH-7 | - | Growth Inhibition Assay | - | IC50=16.2674 μM | SANGER |
HuO-3N1 | - | Growth Inhibition Assay | - | IC50=4.17142 μM | SANGER |
HuO9 | - | Growth Inhibition Assay | - | IC50=32.5282 μM | SANGER |
HuP-T3 | - | Growth Inhibition Assay | - | IC50=18.5888 μM | SANGER |
IA-LM | - | Growth Inhibition Assay | - | IC50=38.0239 μM | SANGER |
IMR-32 | 10 μM | Function Assay | 24 h | inhibits clioquinol-induced phosphorylation of p53 | 22627294 |
J-RT3-T3-5 | - | Growth Inhibition Assay | - | IC50=11.2417 μM | SANGER |
JVM-3 | - | Growth Inhibition Assay | - | IC50=22.506 μM | SANGER |
KALS-1 | - | Growth Inhibition Assay | - | IC50=45.146 μM | SANGER |
KARPAS-299 | - | Growth Inhibition Assay | - | IC50=46.3516 μM | SANGER |
KATO III | 2.5/5/7.5 μM | Growth Inhibition Assay | - | enhances the toxicity of olaparib | 24841718 |
KG-1 | - | Growth Inhibition Assay | - | IC50=16.0996 μM | SANGER |
KM12 | - | Growth Inhibition Assay | - | IC50=9.21142 μM | SANGER |
KNS-62 | - | Growth Inhibition Assay | - | IC50=40.8381 μM | SANGER |
KOSC-2 | - | Growth Inhibition Assay | - | IC50=26.9075 μM | SANGER |
KP-N-YS | - | Growth Inhibition Assay | - | IC50=12.6354 μM | SANGER |
KU-19-19 | - | Growth Inhibition Assay | - | IC50=40.7683 μM | SANGER |
KYSE-450 | - | Growth Inhibition Assay | - | IC50=34.6444 μM | SANGER |
LAMA-84 | - | Growth Inhibition Assay | - | IC50=4.58465 μM | SANGER |
LB1047-RCC | - | Growth Inhibition Assay | - | IC50=22.5879 μM | SANGER |
LB2241-RCC | - | Growth Inhibition Assay | - | IC50=11.7186 μM | SANGER |
LCLC-97TM1 | - | Growth Inhibition Assay | - | IC50=48.202 μM | SANGER |
LoVo | - | Growth Inhibition Assay | - | IC50=6.93239 μM | SANGER |
LXF-289 | - | Growth Inhibition Assay | - | IC50=16.2747 μM | SANGER |
MCF10A | 10 μM | Growth Inhibition Assay | 24 h | potentiates the cytotoxicity of GA | 24150595 |
MCF-7 | 1-100μM | Growth Inhibition Assay | 24 h | inhibits the cell proliferation | 23185347 |
MDA-MB-415 | - | Growth Inhibition Assay | - | IC50=26.5033 μM | SANGER |
MDA-MB-453 | 5-40 μM | Growth Inhibition Assay | 72 h | IC50 of 10 μM | 20053781 |
Mewo | - | Growth Inhibition Assay | - | IC50=22.5073 μM | SANGER |
MFE-280 | - | Growth Inhibition Assay | - | IC50=49.4617 μM | SANGER |
MFM-223 | - | Growth Inhibition Assay | - | IC50=31.8098 μM | SANGER |
MG-63 | - | Growth Inhibition Assay | - | IC50=46.9036 μM | SANGER |
MHH-PREB-1 | - | Growth Inhibition Assay | - | IC50=32.6234 μM | SANGER |
MKN1 | - | Growth Inhibition Assay | - | IC50=34.1101 μM | SANGER |
MLMA | - | Growth Inhibition Assay | - | IC50=19.0557 μM | SANGER |
MS-1 | - | Growth Inhibition Assay | - | IC50=34.9554 μM | SANGER |
MV-4-11 | - | Growth Inhibition Assay | - | IC50=28.5735 μM | SANGER |
NBsusSR | - | Growth Inhibition Assay | - | IC50=43.0725 μM | SANGER |
NCI-H1437 | - | Growth Inhibition Assay | - | IC50=9.8097 μM | SANGER |
NCI-H1648 | - | Growth Inhibition Assay | - | IC50=32.8651 μM | SANGER |
NCI-H1793 | - | Growth Inhibition Assay | - | IC50=16.4712 μM | SANGER |
NCI-H1838 | - | Growth Inhibition Assay | - | IC50=11.1865 μM | SANGER |
NCI-H2030 | - | Growth Inhibition Assay | - | IC50=18.1997 μM | SANGER |
NCI-H2228 | - | Growth Inhibition Assay | - | IC50=40.3662 μM | SANGER |
NCI-H526 | - | Growth Inhibition Assay | - | IC50=49.8163 μM | SANGER |
NCI-H82 | - | Growth Inhibition Assay | - | IC50=17.4573 μM | SANGER |
NCI-SNU-1 | - | Growth Inhibition Assay | - | IC50=17.1269 μM | SANGER |
NEC8 | - | Growth Inhibition Assay | - | IC50=29.5548 μM | SANGER |
NKM-1 | - | Growth Inhibition Assay | - | IC50=43.9558 μM | SANGER |
OVCAR-4 | - | Growth Inhibition Assay | - | IC50=32.8363 μM | SANGER |
PANC-08-13 | - | Growth Inhibition Assay | - | IC50=25.0938 μM | SANGER |
PC-3 | 5-40 μM | Growth Inhibition Assay | 72 h | IC50 of 10 μM | 20053781 |
QIMR-WIL | - | Growth Inhibition Assay | - | IC50=25.1858 μM | SANGER |
Ramos-2G6-4C10 | - | Growth Inhibition Assay | - | IC50=22.96 μM | SANGER |
RS4-11 | - | Growth Inhibition Assay | - | IC50=46.542 μM | SANGER |
RVH-421 | - | Growth Inhibition Assay | - | IC50=27.2921 μM | SANGER |
SH-SY5Y | 10 μM | Function Assay | 24 h | inhibits clioquinol-induced phosphorylation of p53 | 22627294 |
SKG-IIIa | - | Growth Inhibition Assay | - | IC50=36.2561 μM | SANGER |
SK-MEL-28 | - | Growth Inhibition Assay | - | IC50=17.0475 μM | SANGER |
SK-MEL-3 | - | Growth Inhibition Assay | - | IC50=8.28575 μM | SANGER |
SK-MEL-30 | - | Growth Inhibition Assay | - | IC50=24.4662 μM | SANGER |
SK-N-AS | - | Growth Inhibition Assay | - | IC50=46.7822 μM | SANGER |
SK-N-DZ | - | Growth Inhibition Assay | - | IC50=50.0481 μM | SANGER |
SK-NEP-1 | - | Growth Inhibition Assay | - | IC50=37.6744 μM | SANGER |
SK-PN-DW | - | Growth Inhibition Assay | - | IC50=32.1406 μM | SANGER |
SNU-449 | - | Growth Inhibition Assay | - | IC50=22.8748 μM | SANGER |
SW1710 | - | Growth Inhibition Assay | - | IC50=28.0981 μM | SANGER |
SW954 | - | Growth Inhibition Assay | - | IC50=43.1053 μM | SANGER |
SW982 | - | Growth Inhibition Assay | - | IC50=27.9052 μM | SANGER |
T47D | 20 mM | Function Assay | 24 h | prevents IR-induced degradation of IκBα | 21144805 |
TE-11 | - | Growth Inhibition Assay | - | IC50=36.5243 μM | SANGER |
TGBC11TKB | - | Growth Inhibition Assay | - | IC50=39.1408 μM | SANGER |
TYK-nu | - | Growth Inhibition Assay | - | IC50=45.1234 μM | SANGER |
U031 | - | Growth Inhibition Assay | - | IC50=21.1489 μM | SANGER |
VM-CUB-1 | - | Growth Inhibition Assay | - | IC50=15.9849 μM | SANGER |
VMRC-RCZ | - | Growth Inhibition Assay | - | IC50=43.4586 μM | SANGER |
YH-13 | - | Growth Inhibition Assay | - | IC50=22.5123 μM | SANGER |
靶点 | Description | IC50 |
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ATM | IC50:13nM |
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