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CAS No.: 587871-26-9

KU-55933/KU-55933(ATM激酶抑制剂) Catalog No. CSN17114

Synonyms: Ku-55933;ATM Kinase Inhibitor

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

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400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 ATM

IC50:13nM
描述The serine/threonine protein kinase ATM signals can regulate cell cycle and DNA repair components through phosphorylation on the targets such as p53, CHK2, NBS1, and BRCA1, thus playing a central role in the maintenance of genome integrity. KU-55933 is a specific ATM inhibitor with IC50 value of 13nM and Ki value of 2.2nM (measured by ATM kinase activity). After exposure to 5 Gy of irradiation, treatment with 10μM KU-55933 caused increased phosphorylation of p53 at serine 15 site, a marker of ATM activity, in a time-dependent manner in U2OS cells in within 4 hours.

A range of ATM target phosphorylation events, including pH2AX-ser139, pNBS1-ser343, pCHK1-ser345, or pSMC1-ser966, were decreased by pretreatment with 10μM KU-55933 for 1h before irradiation 3Gy or 15Gy in U2OS cells. The radiosensitization by KU-55933 can be observed in HeLa cells pre-treated with 10μM KU-55933 before a range of ionizing radiation (0-4Gy). Also it can sensitize HeLa cells to the cytotoxic effects of the topoisomerase II inhibitors etoposide, doxorubicin, amsacrine and the topoisomerase I inhibitor camptothecin. These suggested that KU-55933 performed as a radio- and chemosensitizer^[1].
作用机制KU-55933 is an ATP-competitive ATM inhibitor.^[1]
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
639-V	-	Growth Inhibition Assay	-	IC50=27.5119 μM	SANGER
697	-	Growth Inhibition Assay	-	IC50=19.0201 μM	SANGER
8305C	-	Growth Inhibition Assay	-	IC50=16.1889 μM	SANGER

更多
动物研究
剂量
Mice: 5 mg/kg^[2] (i.p.), 0.5 mg/kg^[3] (i.p.), 10 mg/kg^[4] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 5 mg/kg^[2] (i.p.), 0.5 mg/kg^[3] (i.p.), 10 mg/kg^[4] (i.p.)
给药途径	i.p.

[1] Hickson I, Zhao Y, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64(24):9152-9.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5285 mL
- 12.6424 mL
- 25.2848 mL
- 5 mM
- 0.5057 mL
- 2.5285 mL
- 5.0570 mL
- 10 mM
- 0.2528 mL
- 1.2642 mL
- 2.5285 mL

技术信息

CAS号

587871-26-9

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H17NO3S2

运输

蓝冰

分子量

395.49

别名

Ku-55933;ATM Kinase Inhibitor

溶解度

DMSO	100.0 mg/mL (252.8 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	6 mg/mL	clear
PO	0.5% CMC-Na	30 mg/mL	suspension

大规格询价

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

639-V	-	Growth Inhibition Assay	-	IC50=27.5119 μM	SANGER
697	-	Growth Inhibition Assay	-	IC50=19.0201 μM	SANGER
8305C	-	Growth Inhibition Assay	-	IC50=16.1889 μM	SANGER
A101D	-	Growth Inhibition Assay	-	IC50=45.4456 μM	SANGER
A2780	-	Growth Inhibition Assay	-	IC50=27.641 μM	SANGER
A29 MEF	10 μM	Function Assay	1h	blocks the phosphorylation of Akt at Ser473	20053781
A549	-	Growth Inhibition Assay	-	IC50=43.931 μM	SANGER
A549	10 μM	Function Assay	1 h	suppresses Nano-Co-induced p53 accumulation	22559321
A704	-	Growth Inhibition Assay	-	IC50=19.8305 μM	SANGER
BALL-1	-	Growth Inhibition Assay	-	IC50=47.832 μM	SANGER
BB30-HNC	-	Growth Inhibition Assay	-	IC50=49.9498 μM	SANGER
BFTC-905	-	Growth Inhibition Assay	-	IC50=25.5944 μM	SANGER
BHT-101	-	Growth Inhibition Assay	-	IC50=28.6572 μM	SANGER
C32	-	Growth Inhibition Assay	-	IC50=40.4024 μM	SANGER
Ca9-22	-	Growth Inhibition Assay	-	IC50=28.714 μM	SANGER
CAL-12T	-	Growth Inhibition Assay	-	IC50=13.617 μM	SANGER
CAL-33	-	Growth Inhibition Assay	-	IC50=42.6749 μM	SANGER
CAL-51	-	Growth Inhibition Assay	-	IC50=40.0612 μM	SANGER
CAL-72	-	Growth Inhibition Assay	-	IC50=5.48084 μM	SANGER
ChaGo-K-1	-	Growth Inhibition Assay	-	IC50=16.6568 μM	SANGER
CHL-1	-	Growth Inhibition Assay	-	IC50=23.7292 μM	SANGER
CHP-134	-	Growth Inhibition Assay	-	IC50=42.8496 μM	SANGER
COLO-684	-	Growth Inhibition Assay	-	IC50=14.1569 μM	SANGER
COLO-829	-	Growth Inhibition Assay	-	IC50=38.4159 μM	SANGER
CTB-1	-	Growth Inhibition Assay	-	IC50=17.2259 μM	SANGER
D-263MG	-	Growth Inhibition Assay	-	IC50=29.344 μM	SANGER
D-283MED	-	Growth Inhibition Assay	-	IC50=20.5339 μM	SANGER
D-423MG	-	Growth Inhibition Assay	-	IC50=15.5236 μM	SANGER
D-566MG	-	Growth Inhibition Assay	-	IC50=49.9096 μM	SANGER
DB	-	Growth Inhibition Assay	-	IC50=37.9185 μM	SANGER
DBTRG-05MG	-	Growth Inhibition Assay	-	IC50=15.6111 μM	SANGER
DEL	-	Growth Inhibition Assay	-	IC50=26.8356 μM	SANGER
DMS-273	-	Growth Inhibition Assay	-	IC50=44.7567 μM	SANGER
DOK	-	Growth Inhibition Assay	-	IC50=15.3329 μM	SANGER
DU-145	-	Growth Inhibition Assay	-	IC50=3.27352 μM	SANGER
EKVX	-	Growth Inhibition Assay	-	IC50=31.5847 μM	SANGER
EM-2	-	Growth Inhibition Assay	-	IC50=31.6304 μM	SANGER
EPLC-272H	-	Growth Inhibition Assay	-	IC50=46.9503 μM	SANGER
ES7	-	Growth Inhibition Assay	-	IC50=11.788 μM	SANGER
ES8	-	Growth Inhibition Assay	-	IC50=34.8975 μM	SANGER
EW-13	-	Growth Inhibition Assay	-	IC50=27.4308 μM	SANGER
FADU	-	Growth Inhibition Assay	-	IC50=41.2502 μM	SANGER
G-361	-	Growth Inhibition Assay	-	IC50=46.2138 μM	SANGER
GCIY	-	Growth Inhibition Assay	-	IC50=16.7905 μM	SANGER
GI-1	-	Growth Inhibition Assay	-	IC50=25.7055 μM	SANGER
GOTO	-	Growth Inhibition Assay	-	IC50=11.6996 μM	SANGER
GT3TKB	-	Growth Inhibition Assay	-	IC50=26.5342 μM	SANGER
HAL-01	-	Growth Inhibition Assay	-	IC50=28.7615 μM	SANGER
HCC1569	-	Growth Inhibition Assay	-	IC50=28.4897 μM	SANGER
HCC1806	-	Growth Inhibition Assay	-	IC50=43.411 μM	SANGER
HCC2157	-	Growth Inhibition Assay	-	IC50=22.8054 μM	SANGER
HCC2998	-	Growth Inhibition Assay	-	IC50=17.6733 μM	SANGER
HCC70	-	Growth Inhibition Assay	-	IC50=19.489 μM	SANGER
HDLM-2	-	Growth Inhibition Assay	-	IC50=42.9084 μM	SANGER
HeLa	1-100μM	Growth Inhibition Assay	24 h	inhibits the cell proliferation	23185347
HepG2	10 μM	Growth Inhibition Assay	24 h	blocks SC-III3-induced S phase arrest	25527123
HepG2	10 μM	Function Assay	24 h	suppresses the phosphorylations of ATM on Ser1981, Chk1 on Ser345, Chk2 on Thr68, and Cdk2 on Tyr15 induced by SC-III3	25527123
HH	-	Growth Inhibition Assay	-	IC50=8.27671 μM	SANGER
HL-60	10 μM	Function Assay	0.5 h	reduces phosphorylation of Chk2	23934411
HO-1-N-1	-	Growth Inhibition Assay	-	IC50=48.9676 μM	SANGER
HOP-92	-	Growth Inhibition Assay	-	IC50=35.9277 μM	SANGER
Hs-578-T	-	Growth Inhibition Assay	-	IC50=15.4182 μM	SANGER
HSC-3	-	Growth Inhibition Assay	-	IC50=21.1835 μM	SANGER
HT-1376	-	Growth Inhibition Assay	-	IC50=46.7426 μM	SANGER
hTCEpi	10 μM	Growth Inhibition Assay	-	prevents the cytopathic effect of HSV-1	24370835
HuH-7	-	Growth Inhibition Assay	-	IC50=16.2674 μM	SANGER
HuO-3N1	-	Growth Inhibition Assay	-	IC50=4.17142 μM	SANGER
HuO9	-	Growth Inhibition Assay	-	IC50=32.5282 μM	SANGER
HuP-T3	-	Growth Inhibition Assay	-	IC50=18.5888 μM	SANGER
IA-LM	-	Growth Inhibition Assay	-	IC50=38.0239 μM	SANGER
IMR-32	10 μM	Function Assay	24 h	inhibits clioquinol-induced phosphorylation of p53	22627294
J-RT3-T3-5	-	Growth Inhibition Assay	-	IC50=11.2417 μM	SANGER
JVM-3	-	Growth Inhibition Assay	-	IC50=22.506 μM	SANGER
KALS-1	-	Growth Inhibition Assay	-	IC50=45.146 μM	SANGER
KARPAS-299	-	Growth Inhibition Assay	-	IC50=46.3516 μM	SANGER
KATO III	2.5/5/7.5 μM	Growth Inhibition Assay	-	enhances the toxicity of olaparib	24841718
KG-1	-	Growth Inhibition Assay	-	IC50=16.0996 μM	SANGER
KM12	-	Growth Inhibition Assay	-	IC50=9.21142 μM	SANGER
KNS-62	-	Growth Inhibition Assay	-	IC50=40.8381 μM	SANGER
KOSC-2	-	Growth Inhibition Assay	-	IC50=26.9075 μM	SANGER
KP-N-YS	-	Growth Inhibition Assay	-	IC50=12.6354 μM	SANGER
KU-19-19	-	Growth Inhibition Assay	-	IC50=40.7683 μM	SANGER
KYSE-450	-	Growth Inhibition Assay	-	IC50=34.6444 μM	SANGER
LAMA-84	-	Growth Inhibition Assay	-	IC50=4.58465 μM	SANGER
LB1047-RCC	-	Growth Inhibition Assay	-	IC50=22.5879 μM	SANGER
LB2241-RCC	-	Growth Inhibition Assay	-	IC50=11.7186 μM	SANGER
LCLC-97TM1	-	Growth Inhibition Assay	-	IC50=48.202 μM	SANGER
LoVo	-	Growth Inhibition Assay	-	IC50=6.93239 μM	SANGER
LXF-289	-	Growth Inhibition Assay	-	IC50=16.2747 μM	SANGER
MCF10A	10 μM	Growth Inhibition Assay	24 h	potentiates the cytotoxicity of GA	24150595
MCF-7	1-100μM	Growth Inhibition Assay	24 h	inhibits the cell proliferation	23185347
MDA-MB-415	-	Growth Inhibition Assay	-	IC50=26.5033 μM	SANGER
MDA-MB-453	5-40 μM	Growth Inhibition Assay	72 h	IC50 of 10 μM	20053781
Mewo	-	Growth Inhibition Assay	-	IC50=22.5073 μM	SANGER
MFE-280	-	Growth Inhibition Assay	-	IC50=49.4617 μM	SANGER
MFM-223	-	Growth Inhibition Assay	-	IC50=31.8098 μM	SANGER
MG-63	-	Growth Inhibition Assay	-	IC50=46.9036 μM	SANGER
MHH-PREB-1	-	Growth Inhibition Assay	-	IC50=32.6234 μM	SANGER
MKN1	-	Growth Inhibition Assay	-	IC50=34.1101 μM	SANGER
MLMA	-	Growth Inhibition Assay	-	IC50=19.0557 μM	SANGER
MS-1	-	Growth Inhibition Assay	-	IC50=34.9554 μM	SANGER
MV-4-11	-	Growth Inhibition Assay	-	IC50=28.5735 μM	SANGER
NBsusSR	-	Growth Inhibition Assay	-	IC50=43.0725 μM	SANGER
NCI-H1437	-	Growth Inhibition Assay	-	IC50=9.8097 μM	SANGER
NCI-H1648	-	Growth Inhibition Assay	-	IC50=32.8651 μM	SANGER
NCI-H1793	-	Growth Inhibition Assay	-	IC50=16.4712 μM	SANGER
NCI-H1838	-	Growth Inhibition Assay	-	IC50=11.1865 μM	SANGER
NCI-H2030	-	Growth Inhibition Assay	-	IC50=18.1997 μM	SANGER
NCI-H2228	-	Growth Inhibition Assay	-	IC50=40.3662 μM	SANGER
NCI-H526	-	Growth Inhibition Assay	-	IC50=49.8163 μM	SANGER
NCI-H82	-	Growth Inhibition Assay	-	IC50=17.4573 μM	SANGER
NCI-SNU-1	-	Growth Inhibition Assay	-	IC50=17.1269 μM	SANGER
NEC8	-	Growth Inhibition Assay	-	IC50=29.5548 μM	SANGER
NKM-1	-	Growth Inhibition Assay	-	IC50=43.9558 μM	SANGER
OVCAR-4	-	Growth Inhibition Assay	-	IC50=32.8363 μM	SANGER
PANC-08-13	-	Growth Inhibition Assay	-	IC50=25.0938 μM	SANGER
PC-3	5-40 μM	Growth Inhibition Assay	72 h	IC50 of 10 μM	20053781
QIMR-WIL	-	Growth Inhibition Assay	-	IC50=25.1858 μM	SANGER
Ramos-2G6-4C10	-	Growth Inhibition Assay	-	IC50=22.96 μM	SANGER
RS4-11	-	Growth Inhibition Assay	-	IC50=46.542 μM	SANGER
RVH-421	-	Growth Inhibition Assay	-	IC50=27.2921 μM	SANGER
SH-SY5Y	10 μM	Function Assay	24 h	inhibits clioquinol-induced phosphorylation of p53	22627294
SKG-IIIa	-	Growth Inhibition Assay	-	IC50=36.2561 μM	SANGER
SK-MEL-28	-	Growth Inhibition Assay	-	IC50=17.0475 μM	SANGER
SK-MEL-3	-	Growth Inhibition Assay	-	IC50=8.28575 μM	SANGER
SK-MEL-30	-	Growth Inhibition Assay	-	IC50=24.4662 μM	SANGER
SK-N-AS	-	Growth Inhibition Assay	-	IC50=46.7822 μM	SANGER
SK-N-DZ	-	Growth Inhibition Assay	-	IC50=50.0481 μM	SANGER
SK-NEP-1	-	Growth Inhibition Assay	-	IC50=37.6744 μM	SANGER
SK-PN-DW	-	Growth Inhibition Assay	-	IC50=32.1406 μM	SANGER
SNU-449	-	Growth Inhibition Assay	-	IC50=22.8748 μM	SANGER
SW1710	-	Growth Inhibition Assay	-	IC50=28.0981 μM	SANGER
SW954	-	Growth Inhibition Assay	-	IC50=43.1053 μM	SANGER
SW982	-	Growth Inhibition Assay	-	IC50=27.9052 μM	SANGER
T47D	20 mM	Function Assay	24 h	prevents IR-induced degradation of IκBα	21144805
TE-11	-	Growth Inhibition Assay	-	IC50=36.5243 μM	SANGER
TGBC11TKB	-	Growth Inhibition Assay	-	IC50=39.1408 μM	SANGER
TYK-nu	-	Growth Inhibition Assay	-	IC50=45.1234 μM	SANGER
U031	-	Growth Inhibition Assay	-	IC50=21.1489 μM	SANGER
VM-CUB-1	-	Growth Inhibition Assay	-	IC50=15.9849 μM	SANGER
VMRC-RCZ	-	Growth Inhibition Assay	-	IC50=43.4586 μM	SANGER
YH-13	-	Growth Inhibition Assay	-	IC50=22.5123 μM	SANGER

KU-55933/KU-55933(ATM激酶抑制剂) Catalog No. CSN17114

靶点选择性

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