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CAS No.: 1000669-72-6
Synonyms: KW-2449
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A, and showing little effect on PDGFRβ, IGF-1R, EGFR.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00779480 | Acute Myelogenous Leukemia (AM... more >>L) Collapse << | Phase 1 | Terminated(Failure to demonstr... more >>ate a tolerable dose that had potential for efficacy.) Collapse << | - | United States, Maryland ... more >> University of Maryland, Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 Johns Hopkins University Baltimore, Maryland, United States, 21231 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, South Carolina St. Francis Hospital Greenville, South Carolina, United States, 29601 Collapse << |
NCT00346632 | Acute Myelogenous Leukemia ... more >> Acute Lymphoblastic Leukemia Myelodysplastic Syndromes Chronic Myelogenous Leukemia Collapse << | Phase 1 | Terminated(Terminated due to s... more >>uboptimal dosing schedule) Collapse << | - | United States, Maryland ... more >> Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, New Jersey Contact Kyowa Princeton, New Jersey, United States, 08540 United States, New York Weill Cornell/New York Presbyterian Hospital New York, New York, United States, 10021 United States, Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT00346632 | - | - | Terminated(Terminated due to s... more >>uboptimal dosing schedule) Collapse << | - | - |
实验方案
技术信息
CAS号 | 1000669-72-6 | 储存条件 |
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分子式 | C20H20N4O | 运输 | 蓝冰 | |
分子量 | 332.40 | 别名 | KW-2449 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00779480 | Acute Myelogenous Leukemia (AM... more >>L) Collapse << | Phase 1 | Terminated(Failure to demonstr... more >>ate a tolerable dose that had potential for efficacy.) Collapse << | - | United States, Maryland ... more >> University of Maryland, Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 Johns Hopkins University Baltimore, Maryland, United States, 21231 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, South Carolina St. Francis Hospital Greenville, South Carolina, United States, 29601 Collapse << |
NCT00346632 | Acute Myelogenous Leukemia ... more >> Acute Lymphoblastic Leukemia Myelodysplastic Syndromes Chronic Myelogenous Leukemia Collapse << | Phase 1 | Terminated(Terminated due to s... more >>uboptimal dosing schedule) Collapse << | - | United States, Maryland ... more >> Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, New Jersey Contact Kyowa Princeton, New Jersey, United States, 08540 United States, New York Weill Cornell/New York Presbyterian Hospital New York, New York, United States, 10021 United States, Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT00346632 | - | - | Terminated(Terminated due to s... more >>uboptimal dosing schedule) Collapse << | - | - |
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