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CAS No.: 142326-59-8

L-701324 Catalog No. CSN17128

Synonyms: L-701324

L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

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技术信息

生物活性

描述L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor. L-701,324 produced a marked increase in the seizure threshold, which was significantly reversed by the administration of glycine^[3]. In contrast to N-methyl-D-aspartate receptor ion channel blockers such as MK-801 (dizocilpine), L-701,324 is a potent, p.o. active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents^[4]. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.). L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia^[5]. Pretreatment with L-701,324 dose-dependently antagonized amphetamine-induced hyperactivity in the mouse (ED50 = 1.12 +/- 0.45 mg/kg p.o.), an effect which was similar to that of the classical neuroleptic, haloperidol, and the atypical neuroleptic, clozapine. In addition, p.o. administration of L-701,324 (2.5 or 5 mg/kg) attenuated the hyperactivity response induced by amphetamine infusion into the rat nucleus accumbens. L-701,324 failed to impair spontaneous locomotor activity or induce catalepsy in the mouse at doses > or = 100 mg/kg^[6]. Moreover, anticonvulsant and neuroprotective actions of L-701,324 may not be associated with marked anaesthesia-like side-effects^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7488 mL
- 13.7440 mL
- 27.4881 mL
- 5 mM
- 0.5498 mL
- 2.7488 mL
- 5.4976 mL
- 10 mM
- 0.2749 mL
- 1.3744 mL
- 2.7488 mL

技术信息

CAS号

142326-59-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H14ClNO3

运输

蓝冰

分子量

363.79

别名

L-701324

溶解度

DMSO	105.0 mg/mL (288.6 mM)
Water	insoluble

动物实验配方

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L-701324 Catalog No. CSN17128

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