CAS No.: 944795-06-6
Lck inhibitor 2 Catalog No. CSN18620
Synonyms: Lck Inhibitor 2
Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00996723 Diffuse Intrinsic Pontine Glio... more >>ma Collapse << Phase 1 Completed - United States, Tennessee ... more >> St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse << NCT02693535 Lymphoma, Non-Hodgkin ... more >> Multiple Myeloma Advanced Solid Tumors Collapse << Phase 2 Recruiting - - NCT00534573 Clozapine-induced Hypersalivat... more >>ion Collapse << Phase 3 Completed - Israel ... more >> Be'er Sheva Mental Health Center, Tirat HaKarmel Mental Health Center Be'er Sheva, Haifa, Israel Collapse << - 参考文献
- [1] Bamborough P, Drewry D, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914.
- [2] Bamborough P, Angell RM, et al. N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 944795-06-6 | 储存条件 |
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| 分子式 | C18H17N5O2 | 运输 | 蓝冰 | |||
| 分子量 | 335.36 | 别名 | Lck Inhibitor 2 | |||
| 溶解度 |
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动物实验配方 |
