CAS No.: 847950-09-8
Lck Inhibitor Catalog No. CSN16563
Synonyms: TC-S 7003
Lck inhibitor is a class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02693535 Lymphoma, Non-Hodgkin ... more >> Multiple Myeloma Advanced Solid Tumors Collapse << Phase 2 Recruiting - - NCT00996723 Diffuse Intrinsic Pontine Glio... more >>ma Collapse << Phase 1 Completed - United States, Tennessee ... more >> St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse << NCT00534573 Clozapine-induced Hypersalivat... more >>ion Collapse << Phase 3 Completed - Israel ... more >> Be'er Sheva Mental Health Center, Tirat HaKarmel Mental Health Center Be'er Sheva, Haifa, Israel Collapse << - 参考文献
- [1] Liew CY, Ma XH, et al. SVM model for virtual screening of Lck inhibitors. J Chem Inf Model. 2009 Apr;49(4):877-85.
- [2] Martin MW, Newcomb J, et al. Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6] pyrimido[1,2-a] benzimidazol-5(6H)-ones aspotent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2008 Mar 27;51(6):1637-48.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 847950-09-8 | 储存条件 |
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| 分子式 | C31H30N8O | 运输 | 蓝冰 | |
| 分子量 | 530.62 | 别名 | TC-S 7003 |
