|(E)-3-(4-羟基-2-甲氧基-5-(2-甲基丁-3-烯-2-基)苯基)-1-(4-羟基苯基)丙-2-烯-1-酮|CsnPharm

CAS No.: 58749-22-7

Licochalcone A/甘草查尔酮 A Catalog No. CSN16424

Synonyms: 甘草查尔酮A

Licochalcone A, an estrogenic flavanoid, can be an inhibitor of p-glycoprotein and has anti-inflammatory actions.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Licochalcone A (LA) is a flavonoid extracted from licorice root and has antiparasitic and anti-tumor activities^[3]. Treatment with LA at 6.25 or 12.5 μM for 24 h down-regulated the expression of Bcl-2 with concomitant enhancement of the conversion of LC3-I to LC3-II and dose-dependently induced apoptosis in LNCaP cells^[4]. BGC cells exposed to LA (100 μM) for 2 or 4 h showed significantly increased intracellular ROS in a concentration-dependent manner, activated ERK, JNK, and p38 but suppressed PI3K and AKT, compared with the control group^[3]. Licochalcone A showed effects against all gram-positive bacteria tested and was especially effective against Bacillus cereus IFO 3514, Bacillus coagulans IFO 12583, Bacillus subtilis IFO 3007 and Bacillus stearothermophilus IFO 12550, with MICs of 2 to 3 μg/mL, but was not effective against gram-negative bacteria or eukaryotes at 50 μg/mL^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02173054	Acne	Phase 3	Completed	-	Thailand ... more >> Siriraj Hospital Mahidol Univeristy Bangkok, Thailand, 10700 Collapse <<
NCT03292822	Squamous Cell Carcinoma	Early Phase 1	Not yet recruiting	April 1, 2019	Egypt ... more >> Cairo University Cairo, Egypt Collapse <<
NCT02173054	-	-	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9551 mL
- 14.7755 mL
- 29.5511 mL
- 5 mM
- 0.5910 mL
- 2.9551 mL
- 5.9102 mL
- 10 mM
- 0.2955 mL
- 1.4776 mL
- 2.9551 mL

技术信息

CAS号

58749-22-7

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22O4

运输

蓝冰

分子量

338.40

别名

甘草查尔酮A

溶解度

DMSO	66.0 mg/mL (195.0 mM)
Water	Insoluble
Ethanol	66.0 mg/mL (195.0 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Licochalcone A/甘草查尔酮 A Catalog No. CSN16424

靶点选择性

请登录您的专属账户

确认信息