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CAS No.: 170632-47-0
Synonyms: LificiguatLificiguatLificiguat;YC-1
Lificiguat is an acivator of guanylyl cyclase (sGC) and can bind to the heme-containing domain of the β subunit with Kd of 0.6 μM - 1.1 μM.
生物活性
实验方案
技术信息
CAS号 | 170632-47-0 | 储存条件 |
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分子式 | C19H16N2O2 | 运输 | 蓝冰 | |||||
分子量 | 304.34 | 别名 | LificiguatLificiguatLificiguat;YC-1 | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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A498 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay, IC50=0.3 μM | 26235951 |
ACHN cells | - | Function assay | 48 h | Antitumor activity against human ACHN cells after 48 hrs by MTT assay | 20097456 |
AGS cells | - | Function assay | - | Inhibition of hypoxia induced HIF1 transcriptional activity in human AGS cells by cell-based HRE reporter assay, IC50=2 μM | 17328532 |
HCT116 cells | - | Cytotoxicity assay | 72 h | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50=2.2 μM | 24900662 |
HEK293 cells | - | Function assay | 16 h | Inhibition of hypoxia-induced HIF1alpha transcriptional activity in HEK293 cells incubated for 16 hrs by hypoxia response element-driven luciferase reporter gene assay, IC50=9.21 μM | 19435661 |
HeLa cells | - | Function assay | - | Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assay, IC50=1.5 μM | 24900662 |
Hep3B cells | - | Function assay | - | Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human Hep3B cells by reporter gene assay, IC50=13.8 μM | 17884495 |
HepG2 cells | - | Cytotoxicity assay | 72 h | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=2.2 μM | 24900662 |
HL60 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=25.27 μM | 23831809 |
HT1080 cells | - | Function assay | - | Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay, IC50=48.4 μM | 25773014 |
NCI-H226 cells | - | Function assay | 48 h | Antitumor activity against human NCI-H226 cells after 48 hrs by MTT assay, IC50=1.9 μM | 20097456 |
U251HRE cells | - | Function assay | - | Inhibition of hypoxia-induced HIF1 activation in human U251HRE cells by cell based reporter gene assay, IC50=14.8 μM | 18501601 |
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