CAS No.: 105431-72-9
Linopirdine Catalog No. CSN20022
Synonyms: DuP 996
Linopirdine is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Greene DL, Kang S, Hoshi N. XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits. J Pharmacol Exp Ther. 2017 May 8. pii: jpet.117.241679.
- [2] Kang SW, Ahn JW, Ahn SC. Inhibition of K(+) outward currents by linopirdine in the cochlear outer hair cells of circling mice within the first postnatal week. Korean J Physiol Pharmacol. 2017 Mar;21(2):251-257.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 105431-72-9 | 储存条件 |
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| 分子式 | C26H21N3O | 运输 | 蓝冰 | |
| 分子量 | 391.46 | 别名 | DuP 996 |
