CAS No.: 1192189-69-7
LX7101 Catalog No. CSN17539
LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively and also inhibits PKA with an IC50 less than 1 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01528111 Primary Open-angle Glaucoma ... more >> Ocular Hypertension Collapse << Phase 1 Phase 2 Completed - United States, Georgia ... more >> Lexicon Investigational Site Morrow, Georgia, United States, 30260 United States, Tennessee Lexicon Investigational Site Memphis, Tennessee, United States, 38119 United States, Texas Lexicon Investigational Site Austin, Texas, United States, 78731 Lexicon Investigational Site Houston, Texas, United States, 77025 Lexicon Investigational Site San Antonio, Texas, United States, 78209 Collapse << - 参考文献
- [1] Boland S, Bourin A, et al. Design, synthesis and biological characterization of selective LIMK inhibitors. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4005-10.
- [2] Harrison BA, Almstead ZY, et al. Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma. ACS Med Chem Lett. 2014 Nov 24;6(1):84-8.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1192189-69-7 | 储存条件 |
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| 分子式 | C23H29N7O3 | 运输 | 蓝冰 | |
| 分子量 | 451.52 | 别名 |
