CAS No.: 558447-26-0
Mavorixafor Catalog No. CSN13161
Synonyms: AMD-070;AMD-11070;X4P-001
AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
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- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02680782 Healthy Phase 1 Terminated - United States, Florida ... more >> Covance CRU, Inc. Daytona Beach, Florida, United States, 32117 Collapse << NCT03005327 WHIM Syndrome Phase 2 Phase 3 Recruiting August 2019 United States, Florida ... more >> University of South Florida Recruiting Saint Petersburg, Florida, United States, 33701 United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109 United States, Washington University of Washingington Medical Center Recruiting Seattle, Washington, United States, 98195 Australia, Victoria St. Vincent's Hospital Recruiting Fitzroy, Victoria, Australia, 3065 Collapse << NCT02823405 Melanoma Phase 1 Recruiting October 2017 United States, Georgia ... more >> Clinical Site Recruiting Atlanta, Georgia, United States, 30322 United States, Iowa Clinical Site Recruiting Iowa City, Iowa, United States, 52242 United States, Texas Clinical Site Recruiting Houston, Texas, United States, 77030 United States, Utah Clinical Site Recruiting Salt Lake City, Utah, United States, 84112 Collapse << - 更多
- 参考文献
- [1] Skerlj R, Bridger G, et al. Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1414-8.
- [2] Skerlj RT, Bridger GJ, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 558447-26-0 | 储存条件 |
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| 分子式 | C21H27N5 | 运输 | 蓝冰 | |
| 分子量 | 349.47 | 别名 | AMD-070;AMD-11070;X4P-001;X49001 |
