|3-(3,4-二羟基苯基)丙烯酸甲酯|CsnPharm

CAS No.: 3843-74-1

Methyl caffeate/咖啡酸甲酯 Catalog No. CSN29484

Synonyms: Caffeic Acid methyl ester;Methyl Caffeate;Methyl 3,4-dihydroxycinnamate

Methyl caffeate is an α-glucosidase inhibitor found in species of Solanum and Magnolia. It exhibits several biological activities, including suppressing growth of Pseudomonas, Klebsiella, and Mycobacterium, inhibiting replication of HIV, and decreasing blood glucose levels in models of diabetes.

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400-920-2911

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技术信息

生物活性

描述Caffeic acid methyl ester displays antioxidant, antiproliferative and cytotoxic properties. Caffeic acid methyl ester exhibits a strong inhibitory effect on human platelet aggregation. A synthetic dihydrobenzofuran lignan (Q2-3), the dimerization product of plant caffeic acid methyl ester, suppresses 4T1 metastasis by increasing fibroblastic IL-25 activity. The secretion of IL-25 from treated human or mouse fibroblasts is enhanced in vitro, and this activity confers a strong suppressive effect on growth activity of test carcinoma cells^[1]. DMAB (a colon and mammary carcinogen)-induced mutagenicity was significantly inhibited with 150 microM MC (methyl caffeate), 40-60 microM PEC (phenylethyl caffeate) and 40-80 microM PEDMC (phenylethyl dimethylcaffeate) in both tester systems. Treatment of HT-29 colon adenocarcinoma cells with > 150 microM MC, 30 microM PEC and 20 microM PEDMC significantly inhibited the cell growth and syntheses of RNA, DNA and protein. ODC and PTK activities were also inhibited in HT-29 cells treated with different concentrations of MC, PEC and PEDMC^[2].
参考文献

[1] Yin SY, Jian FY, Chen YH, Chien SC, Hsieh MC, Hsiao PW, Lee WH, Kuo YH, Yang NS. Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis. Nat Commun. 2016 Apr 18;7:11311
[2] Rao CV, Desai D, Kaul B, Amin S, Reddy BS. Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth. Chem Biol Interact. 1992 Nov 16;84(3):277-90

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.1498 mL
- 25.7488 mL
- 51.4975 mL
- 5 mM
- 1.0300 mL
- 5.1498 mL
- 10.2995 mL
- 10 mM
- 0.5150 mL
- 2.5749 mL
- 5.1498 mL

技术信息

CAS号	3843-74-1	储存条件	粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C10H10O4	运输	蓝冰
分子量	194.18	别名	Caffeic Acid methyl ester;Methyl Caffeate;Methyl 3,4-dihydroxycinnamate;Caffeic acid;methyl ester;咖啡酸甲酯

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