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CAS No.: 1084-65-7

Meticrane/美替克仑 Catalog No. CSN11424

Synonyms: 美替克仑

Meticrane is a diuretic and a potent peripheral-type benzodiazepine receptor (PBR) inhibitor (IC50= 1 μM).

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生物活性

描述Meticrane is a diuretic and a potent peripheral-type benzodiazepine receptor (PBR) inhibitor (IC50= 1 μM). Meticrane inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension^[3]. Meticrane is highly ranked in the connectivity map (cMap) analysis, and it does not have any known anti-cancer or immune-stimulating effect. Co-treatment with Meticrane significantly enhances treatment efficacy of CTLA-4 blockade^[4]. In vitro assays performed in presence of 6-hydroxycoumarin and meticrane, among the highly affinity predicted binders, confirmed a dose-dependent inhibition (17-81%) of patulin production by 6-hydroxycoumarin (10 µM-1 mM concentration range), whereas the approved drug meticrane inhibited patulin production by 43% already at 10 µM. Furthermore, 6-hydroxycoumarin and meticrane caused a 60 and 41% reduction of patulin production, respectively, in vivo on apples at 100 µg/wound^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6318 mL
- 18.1591 mL
- 36.3181 mL
- 5 mM
- 0.7264 mL
- 3.6318 mL
- 7.2636 mL
- 10 mM
- 0.3632 mL
- 1.8159 mL
- 3.6318 mL

技术信息

CAS号

1084-65-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H13NO4S2

运输

蓝冰

分子量

275.34

别名

美替克仑

溶解度

DMSO	55.0 mg/mL (199.7 mM)
Water	Insoluble
Ethanol	Insoluble

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