CAS No.: 1313881-70-7
Miransertib Catalog No. CSN17685
Synonyms: ARQ-092
ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02476955 Solid Tumors ... more >>Ovarian Cancer Endometrial Cancer Collapse << Phase 1 Phase 2 Recruiting June 2021 United States, Michigan ... more >> Completed Grand Rapids, Michigan, United States, 49503 United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 United States, Oklahoma University of Oklahoma Health Sciences Center Not yet recruiting Oklahoma City, Oklahoma, United States, 73104 United States, Texas MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 Completed San Antonio, Texas, United States, 78229 Collapse << - 参考文献
- [1] Wang J, Chandrasekhar V, et al. In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy. PLoS One. 2017 Jun 5;12(6):e0178905.
- [2] Lapierre JM, Eathiraj S, et al. Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b] pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. J Med Chem. 2016 Jul 14;59(13):6455-69.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1313881-70-7 | 储存条件 |
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| 分子式 | C27H24N6 | 运输 | 蓝冰 | |
| 分子量 | 432.52 | 别名 | ARQ-092 |
