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CAS No.: 391210-10-9
Synonyms: PD0325901;PD325901;mirdametinib
PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
生物活性
靶点 | MEK IC50:0.33nM |
动物研究 | |||||||||||||
剂量 | Pig: 0.79 mg/kg[4] (p.o.) | ||||||||||||
给药途径 | p.o., i.p., i.v. | ||||||||||||
动物药代数据 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03170206 | Lung Cancer | Phase 1 Phase 2 | Recruiting | March 31, 2024 | United States, Massachusetts ... more >> Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Geoffrey Shapiro, MD, PhD 617-632-4942 Principal Investigator: Geoffrey Shapiro, MD Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02215 Contact: Rebecca Heist, MD 617-726-1838 Principal Investigator: Rebecca Heist, MD Collapse << |
NCT02510001 | Solid Tumor C... more >>olorectal Cancer Collapse << | Phase 1 | Active, not recruiting | September 2019 | United Kingdom ... more >> Oxford University Hospital NHS Trust Oxford, United Kingdom, OX3 7LE Collapse << |
NCT01347866 | - | - | Terminated(Refer to Detailed D... more >>escription for documentaion of Termination Statement.) Collapse << | - | - |
实验方案
技术信息
CAS号 | 391210-10-9 | 储存条件 |
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分子式 | C16H14F3IN2O4 | 运输 | 蓝冰 | |||||||||||
分子量 | 482.19 | 别名 | PD0325901;PD325901;mirdametinib | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human A101D cell | - | Growth inhibition assay | - | Inhibition of human A101D cell growth in a cell viability assay, IC50=11.45 nM. | SANGER |
human A375 cell | - | Growth inhibition assay | - | Inhibition of human A375 cell growth in a cell viability assay, IC50=2.69 nM. | SANGER |
human A375 cells | - | Proliferation assay | 72 h | Antiproliferative activity against human A375 cells expressing BRAF V600E mutant after 72 hrs by Cell titer-glo assay, IC50=13 nM. | 23474388 |
human A549 cell | - | Growth inhibition assay | - | Inhibition of human A549 cell growth in a cell viability assay, IC50=7.89 nM. | SANGER |
human ABC-1 cell | - | Growth inhibition assay | - | Inhibition of human ABC-1 cell growth in a cell viability assay, IC50=123.02 nM. | SANGER |
human ACN cell | - | Growth inhibition assay | - | Inhibition of human ACN cell growth in a cell viability assay, IC50=15.76 nM. | SANGER |
human AGS cell | - | Growth inhibition assay | - | Inhibition of human AGS cell growth in a cell viability assay, IC50=20.41 nM. | SANGER |
human AsPC-1 cell | - | Growth inhibition assay | - | Inhibition of human AsPC-1 cell growth in a cell viability assay, IC50=45.28 nM. | SANGER |
human BB30-HNC cell | - | Growth inhibition assay | - | Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50=85.51 nM. | SANGER |
human BHT-101 cell | - | Growth inhibition assay | - | Inhibition of human BHT-101 cell growth in a cell viability assay, IC50=6.7 nM. | SANGER |
human BPH-1 cell | - | Growth inhibition assay | - | Inhibition of human BPH-1 cell growth in a cell viability assay, IC50=3.95 nM. | SANGER |
human C2BBe1 cell | - | Growth inhibition assay | - | Inhibition of human C2BBe1 cell growth in a cell viability assay, IC50=28.54 nM. | SANGER |
human C32 cell | - | Growth inhibition assay | - | Inhibition of human C32 cell growth in a cell viability assay, IC50=3.67 nM. | SANGER |
human CAL-27 cell | - | Growth inhibition assay | - | Inhibition of human CAL-27 cell growth in a cell viability assay, IC50=44.91 nM | SANGER |
human CAL-39 cell | - | Growth inhibition assay | - | Inhibition of human CAL-39 cell growth in a cell viability assay, IC50=39.04 nM. | SANGER |
human CAL-62 cell | - | Growth inhibition assay | - | Inhibition of human CAL-62 cell growth in a cell viability assay, IC50=100.78 nM. | SANGER |
human CHP-212 cell | - | Growth inhibition assay | - | Inhibition of human CHP-212 cell growth in a cell viability assay, IC50=0.527 nM. | SANGER |
human COLO-679 cell | - | Growth inhibition assay | - | Inhibition of human COLO-679 cell growth in a cell viability assay, IC50=10.01 nM | SANGER |
human COLO-741 cell | - | Growth inhibition assay | - | Inhibition of human COLO-741 cell growth in a cell viability assay, IC50=7.1 nM. | SANGER |
human COLO-792 cell | - | Growth inhibition assay | - | Inhibition of human COLO-792 cell growth in a cell viability assay, IC50=43.15 nM. | SANGER |
human COR-L105 cell | - | Growth inhibition assay | - | Inhibition of human COR-L105 cell growth in a cell viability assay, IC50=71.71 nM. | SANGER |
human CP50-MEL-B cell | - | Growth inhibition assay | - | Inhibition of human CP50-MEL-B cell growth in a cell viability assay, IC50=4.58 nM. | SANGER |
human DOK cell | - | Growth inhibition assay | - | Inhibition of human DOK cell growth in a cell viability assay, IC50=13.4 nM. | SANGER |
human DU-4475 cell | - | Growth inhibition assay | - | Inhibition of human DU-4475 cell growth in a cell viability assay, IC50=3.57 nM. | SANGER |
human EGI-1 cell | - | Growth inhibition assay | - | Inhibition of human EGI-1 cell growth in a cell viability assay, IC50=95.81 nM. | SANGER |
human EM-2 cell | - | Growth inhibition assay | - | Inhibition of human EM-2 cell growth in a cell viability assay, IC50=74.7 nM. | SANGER |
human GAK cell | - | Growth inhibition assay | - | Inhibition of human GAK cell growth in a cell viability assay, IC50=66.87 nM. | SANGER |
human H9 cell | - | Growth inhibition assay | - | Inhibition of human H9 cell growth in a cell viability assay, IC50=5.77 nM. | SANGER |
human HCC1419 cell | - | Growth inhibition assay | - | Inhibition of human HCC1419 cell growth in a cell viability assay, IC50=91.38 nM. | SANGER |
human HCC2998 cell | - | Growth inhibition assay | - | Inhibition of human HCC2998 cell growth in a cell viability assay, IC50=33.66 nM. | SANGER |
human HCC70 cell | - | Growth inhibition assay | - | Inhibition of human HCC70 cell growth in a cell viability assay, IC50=63.01 nM. | SANGER |
human HD-MY-Z cell | - | Growth inhibition assay | - | Inhibition of human HD-MY-Z cell growth in a cell viability assay, IC50=71.12 nM. | SANGER |
human H-EMC-SS cell | - | Growth inhibition assay | - | Inhibition of human H-EMC-SS cell growth in a cell viability assay, IC50=11.02 nM. | SANGER |
human HL-60 cell | - | Growth inhibition assay | - | Inhibition of human HL-60 cell growth in a cell viability assay, IC50=11.15 nM. | SANGER |
human HN cell growth | - | Growth inhibition assay | - | Inhibition of human HN cell growth in a cell viability assay, IC50=122.59 nM. | SANGER |
human HO-1-N-1 cell | - | Growth inhibition assay | - | Inhibition of human HO-1-N-1 cell growth in a cell viability assay, IC50=34.43 nM. | SANGER |
human Hs-578-T cell | - | Growth inhibition assay | - | Inhibition of human Hs-578-T cell growth in a cell viability assay, IC50=12.79 nM. | SANGER |
human HT-1080 cell | - | Growth inhibition assay | - | Inhibition of human HT-1080 cell growth in a cell viability assay, IC50=85.88 nM. | SANGER |
human HT-144 cell | - | Growth inhibition assay | - | Inhibition of human HT-144 cell growth in a cell viability assay, IC50=8.97 nM. | SANGER |
human HT-29 cell | - | Growth inhibition assay | - | Inhibition of human HT-29 cell growth in a cell viability assay, IC50=50.49 nM. | SANGER |
human HTC-C3 cell | - | Growth inhibition assay | - | Inhibition of human HTC-C3 cell growth in a cell viability assay, IC50=5.89 nM. | SANGER |
human HuP-T3 cell | - | Growth inhibition assay | - | Inhibition of human HuP-T3 cell growth in a cell viability assay, IC50=83.93 nM. | SANGER |
human HuP-T4 cell | - | Growth inhibition assay | - | Inhibition of human HuP-T4 cell growth in a cell viability assay, IC50=10.98 nM. | SANGER |
human IA-LM cell | - | Growth inhibition assay | - | Inhibition of human IA-LM cell growth in a cell viability assay, IC50=73.28 nM. | SANGER |
human KNS-62 cell | - | Growth inhibition assay | - | Inhibition of human KNS-62 cell growth in a cell viability assay, IC50=69.99 nM. | SANGER |
human KY821 cell | - | Growth inhibition assay | - | Inhibition of human KY821 cell growth in a cell viability assay, IC50=53.3 nM. | SANGER |
human LAMA-84 cell | - | Growth inhibition assay | - | Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50=94.68 nM. | SANGER |
human LB1047-RCC cell | - | Growth inhibition assay | - | Inhibition of human LB1047-RCC cell growth in a cell viability assay, IC50=59.65 nM. | SANGER |
human LB2241-RCC cell | - | Growth inhibition assay | - | Inhibition of human LB2241-RCC cell growth in a cell viability assay, IC50=65.52 nM. | SANGER |
human LB2518-MEL cell | - | Growth inhibition assay | - | Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50=11.13 nM. | SANGER |
human LoVo cell | - | Growth inhibition assay | - | Inhibition of human LoVo cell growth in a cell viability assay, IC50=65.29 nM. | SANGER |
human LOXIMVI cell | - | Growth inhibition assay | - | Inhibition of human LOXIMVI cell growth in a cell viability assay, IC50=39.39 nM. | SANGER |
human LS-513 cell | - | Growth inhibition assay | - | Inhibition of human LS-513 cell growth in a cell viability assay, IC50=114.83 nM. | SANGER |
human M14 cell | - | Growth inhibition assay | - | Inhibition of human M14 cell growth in a cell viability assay, IC50=1.45 nM. | SANGER |
human MCF7 cells | - | Function assay | 75 mins | Inhibition of MEk1/2 in human MCF7 cells assessed as decrease in ERK phosphorylation after 75 mins by Western blotting analysis | 23398453 |
human MDA-MB-175-VII cell | - | Growth inhibition assay | - | Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay | SANGER |
human MEG-01 cell | - | Growth inhibition assay | - | Inhibition of human MEG-01 cell growth in a cell viability assay, IC50=97.77 nM. | SANGER |
human MEL-HO cell | - | Growth inhibition assay | - | Inhibition of human MEL-HO cell growth in a cell viability assay, IC50=9.49 nM. | SANGER |
human Mewo cell | - | Growth inhibition assay | - | Inhibition of human Mewo cell growth in a cell viability assay, IC50=14.45 nM. | SANGER |
human MIA-PaCa-2 cell | - | Growth inhibition assay | - | Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay, IC50=63.53 nM. | SANGER |
human MIAPaCa2 cells | - | Proliferation assay | - | Antiproliferative activity against human MIAPaCa2 cells, IC50=17 nM. | 23474388 |
human MV-4-11 cell | - | Growth inhibition assay | - | Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50=94.73 nM. | SANGER |
human MZ2-MEL cell | - | Growth inhibition assay | - | Inhibition of human MZ2-MEL cell growth in a cell viability assay, IC50=35.65 nM. | SANGER |
human MZ7-mel cell | - | Growth inhibition assay | - | Inhibition of human MZ7-mel cell growth in a cell viability assay, IC50=29.43 nM. | SANGER |
human NB10 cell | - | Growth inhibition assay | - | Inhibition of human NB10 cell growth in a cell viability assay, IC50=100.42 nM. | SANGER |
human NB69 cell | - | Growth inhibition assay | - | Inhibition of human NB69 cell growth in a cell viability assay | SANGER |
human NCI-H1437 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H1437 cell growth in a cell viability assay, IC50=34.49 nM. | SANGER |
human NCI-H1666 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H1666 cell growth in a cell viability assay, IC50=11.17 nM. | SANGER |
human NCI-H2087 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H2087 cell growth in a cell viability assay, IC50=101.14 nM. | SANGER |
human NCI-H2291 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H2291 cell growth in a cell viability assay, IC50=46.46 nM. | SANGER |
human NCI-H292 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H292 cell growth in a cell viability assay, IC50=47.39 nM. | SANGER |
human NCI-H747 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H747 cell growth in a cell viability assay, IC50=34.98 nM. | SANGER |
human NCI-SNU-1 cell | - | Growth inhibition assay | - | Inhibition of human NCI-SNU-1 cell growth in a cell viability assay, IC50=96.73 nM. | SANGER |
human NOMO-1 cell | - | Growth inhibition assay | - | Inhibition of human NOMO-1 cell growth in a cell viability assay, IC50=2.07 nM. | SANGER |
human OMC-1 cell | - | Growth inhibition assay | - | Inhibition of human OMC-1 cell growth in a cell viability assay, IC50=100.23 nM. | SANGER |
human ONS-76 cell | - | Growth inhibition assay | - | Inhibition of human ONS-76 cell growth in a cell viability assay, IC50=14.51 nM. | SANGER |
human OVCAR-5 cell | - | Growth inhibition assay | - | Inhibition of human OVCAR-5 cell growth in a cell viability assay, IC50=7.82 nM. | SANGER |
human P12-ICHIKAWA cell | - | Growth inhibition assay | - | Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay, IC50=62.27 nM. | SANGER |
human PANC1 cells | 10 μM | Function assay | 1 h | Inhibition of MEK1 in human PANC1 cells assessed as reduction in pErk1/2 level at 10 uM after 1 hr by Western blotting analysis | 25766633 |
human PSN1 cell | - | Growth inhibition assay | - | Inhibition of human PSN1 cell growth in a cell viability assay, IC50=38.45 nM | SANGER |
human RCM-1 cell | - | Growth inhibition assay | - | Inhibition of human RCM-1 cell growth in a cell viability assay, IC50=46.85 nM. | SANGER |
human RD cell | - | Growth inhibition assay | - | Inhibition of human RD cell growth in a cell viability assay, IC50=67.1 nM. | SANGER |
human RKO cell growth | - | Growth inhibition assay | - | Inhibition of human RKO cell growth in a cell viability assay, IC50=52.02 nM. | SANGER |
human RMG-I cell | - | Growth inhibition assay | - | Inhibition of human RMG-I cell growth in a cell viability assay, IC50=87.34 nM. | SANGER |
human RT-112 cell | - | Growth inhibition assay | - | Inhibition of human RT-112 cell growth in a cell viability assay, IC50=48.84 nM. | SANGER |
human RVH-421 cell | - | Growth inhibition assay | - | Inhibition of human RVH-421 cell growth in a cell viability assay, IC50=12.64 nM. | SANGER |
human SH-4 cell growth | - | Growth inhibition assay | - | Inhibition of human SH-4 cell growth in a cell viability assay, IC50=8.26 nM. | SANGER |
human SJSA-1 cell | - | Growth inhibition assay | - | Inhibition of human SJSA-1 cell growth in a cell viability assay, IC50=123.19 nM. | SANGER |
human SK-MEL-2 cell | - | Growth inhibition assay | - | Inhibition of human SK-MEL-2 cell growth in a cell viability assay, IC50=35.2 nM. | SANGER |
human SK-MEL-28 cell | - | Growth inhibition assay | - | Inhibition of human SK-MEL-28 cell growth in a cell viability assay, IC50=1.52 nM. | SANGER |
human SK-N-AS cell | - | Growth inhibition assay | - | Inhibition of human SK-N-AS cell growth in a cell viability assay, IC50=8.44 nM. | SANGER |
human SNU-387 cell | - | Growth inhibition assay | - | Inhibition of human SNU-387 cell growth in a cell viability assay, IC50=93.36 nM | SANGER |
human SW1116 cell | - | Growth inhibition assay | - | Inhibition of human SW1116 cell growth in a cell viability assay, IC50=60.49 nM. | SANGER |
human SW620 cell | - | Growth inhibition assay | - | Inhibition of human SW620 cell growth in a cell viability assay, IC50=14.95 nM. | SANGER |
human SW626 cell | - | Growth inhibition assay | - | Inhibition of human SW626 cell growth in a cell viability assay, IC50=14.91 nM. | SANGER |
human SW756 cell | - | Growth inhibition assay | - | Inhibition of human SW756 cell growth in a cell viability assay, IC50=34.45 nM. | SANGER |
human SW780 cell | - | Growth inhibition assay | - | Inhibition of human SW780 cell growth in a cell viability assay, IC50=92.32 nM. | SANGER |
human SW872 cell | - | Growth inhibition assay | - | Inhibition of human SW872 cell growth in a cell viability assay, IC50=27.99 nM. | SANGER |
human T-24 cell | - | Growth inhibition assay | - | Inhibition of human T-24 cell growth in a cell viability assay, IC50=19.71 nM. | SANGER |
human TYK-nu cell | - | Growth inhibition assay | - | Inhibition of human TYK-nu cell growth in a cell viability assay, IC50=15.13 nM. | SANGER |
human UACC-257 cell | - | Growth inhibition assay | - | Inhibition of human UACC-257 cell growth in a cell viability assay, IC50=14.62 nM. | SANGER |
human WM-115 cell | - | Growth inhibition assay | - | Inhibition of human WM-115 cell growth in a cell viability assay, IC50=48.5 nM. | SANGER |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03170206 | Lung Cancer | Phase 1 Phase 2 | Recruiting | March 31, 2024 | United States, Massachusetts ... more >> Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Geoffrey Shapiro, MD, PhD 617-632-4942 Principal Investigator: Geoffrey Shapiro, MD Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02215 Contact: Rebecca Heist, MD 617-726-1838 Principal Investigator: Rebecca Heist, MD Collapse << |
NCT02510001 | Solid Tumor C... more >>olorectal Cancer Collapse << | Phase 1 | Active, not recruiting | September 2019 | United Kingdom ... more >> Oxford University Hospital NHS Trust Oxford, United Kingdom, OX3 7LE Collapse << |
NCT01347866 | - | - | Terminated(Refer to Detailed D... more >>escription for documentaion of Termination Statement.) Collapse << | - | - |
NCT01347866 | Advanced Cancer | Phase 1 | Terminated(Refer to Detailed D... more >>escription for documentaion of Termination Statement.) Collapse << | - | United States, California ... more >> Ronald Reagan UCLA Medical Center Los Angeles, California, United States, 90095-6984 Ronald Reagan UCLA Medical Center Los Angeles, California, United States, 90095 UCLA Medical Center Los Angeles, California, United States, 90095 UCLA Oncology Center Los Angeles, California, United States, 90095 Santa Monica - UCLA Medical Center and Orthopaedic Hospital Santa Monica, California, United States, 90404 UCLA Santa Monica Hematology Oncology Santa Monica, California, United States, 90404 United States, Colorado Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 University of Colorado Denver (CTRC) Aurora, Colorado, United States, 80045 University of Colorado Hospital Anschutz Inpatient Pavilion Aurora, Colorado, United States, 80045 University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, South Carolina Medical University of South Carolina, Hollings Cancer Center Charleston, South Carolina, United States, 29425 Medical University of South Carolina Charleston, South Carolina, United States, 29425 MUSC, Investigational Drug Services Charleston, South Carolina, United States, 29425 MUSC Health East Cooper Mount Pleasant, South Carolina, United States, 29464 MUSC Specialty Care-North North Charleston, South Carolina, United States, 29406 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Italy Ospedale San Raffaele Milano, Italy, 20132 Spain Hospital General Vall d'Hebron Barcelona, Spain, 08035 Collapse << |
NCT00147550 | Melanoma Colo... more >>nic Neoplasms Breast Neoplasms Collapse << | Phase 1 Phase 2 | Terminated(See termination rea... more >>son in detailed description.) Collapse << | - | United States, Alabama ... more >> Pfizer Investigational Site Birmingham, Alabama, United States, 35233-2115 Pfizer Investigational Site Birmingham, Alabama, United States, 35233 Pfizer Investigational Site Birmingham, Alabama, United States, 35294 United States, California Pfizer Investigational Site La Jolla, California, United States, 92037 Pfizer Investigational Site La Jolla, California, United States, 92093 Pfizer Investigational Site La Mesa, California, United States, 91942 Pfizer Investigational Site Los Angeles, California, United States, 90025 Pfizer Investigational Site San Diego, California, United States, 92103 Pfizer Investigational Site San Diego, California, United States, 92123 Pfizer Investigational Site Santa Monica, California, United States, 90404 United States, Florida Pfizer Investigational Site Tampa, Florida, United States, 33612 United States, Michigan Pfizer Investigational Site Detroit, Michigan, United States, 48201 Pfizer Investigational Site Detroit, Michigan, United States, 48202 United States, Minnesota Pfizer Investigational Site Rochester, Minnesota, United States, 55905 United States, New York Pfizer Investigational Site New York, New York, United States, 10021 Pfizer Investigational Site New York, New York, United States, 10022 United States, Ohio Pfizer Investigational Site Cleveland, Ohio, United States, 44106 Collapse << |
NCT00174369 | Carcinoma, Non-Small-Cell Lung | Phase 2 | Terminated(Terminated [See Det... more >>ailed Description for Termination Reason.]) Collapse << | - | United States, California ... more >> Pfizer Investigational Site Greenbrae, California, United States, 94904 Pfizer Investigational Site La Jolla, California, United States, 92093 Pfizer Investigational Site LaJolla, California, United States, 92037 Pfizer Investigational Site San Diego, California, United States, 92103 Pfizer Investigational Site San Mateo, California, United States, 94402 United States, Florida Pfizer Investigational Site Tampa, Florida, United States, 33612 United States, Michigan Pfizer Investigational Site Ann Arbor, Michigan, United States, 48106-0995 Pfizer Investigational Site Detroit, Michigan, United States, 48201 Pfizer Investigational Site Farmington Hills, Michigan, United States, 48334 United States, Minnesota Pfizer Investigational Site Coon Rapids, Minnesota, United States, 55433 Pfizer Investigational Site Fridley, Minnesota, United States, 55432 Pfizer Investigational Site Robbinsdale, Minnesota, United States, 55422 United States, New York Pfizer Investigational Site New York, New York, United States, 11725 United States, Pennsylvania Pfizer Investigational Site Philadelphia, Pennsylvania, United States, 19111 Collapse << |
NCT02297802 | - | - | - | - | United States, California ... more >> Sharp Healthcare San Diego, California, United States, 92123 Collapse << |
NCT02039336 | Colorectal Cancer | Phase 1 Phase 2 | Recruiting | December 2019 | Netherlands ... more >> The Netherlands Cancer Institute Recruiting Amsterdam, Netherlands, 1066CX Contact: F opdam, MD, PhD +31 20 512 2446 f.opdam@nki.nl Erasmus Medical Center Cancer Institute Recruiting Rotterdam, Netherlands, 3015CE University Medical Center Utrecht Recruiting Utrecht, Netherlands, 3584CX Collapse << |
NCT02096471 | Neurofibromatosis Type 1 and G... more >>rowing or Symptomatic, Inoperable PN Collapse << | Phase 2 | Active, not recruiting | December 2018 | United States, California ... more >> Children's Hospital Los Angeles Los Angeles, California, United States, 90027 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 United States, Indiana Indiana Unversity Indianapolis, Indiana, United States, 46202 United States, Maryland National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 United States, Massachusetts Children's Hospital Boston Boston, Massachusetts, United States, 02115 United States, Missouri Washington University - St. Louis Saint Louis, Missouri, United States, 63110 United States, New York New York University Medical Center New York, New York, United States, 10016 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19096 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 Collapse << |
NCT02022982 | KRAS Mutant Non-Small Cell Lun... more >>g Cancer Solid Tumors Collapse << | Phase 1 Phase 2 | Active, not recruiting | December 2020 | United States, Massachusetts ... more >> Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
靶点 | Description | IC50 |
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MEK | IC50:0.33nM |
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