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CAS No.: 219315-22-7

Mitochondrial fusion promoter M1/线粒体融合启动子M1 Catalog No. CSN27754

Synonyms: Mitochondrial fusion promoter M1

Mitochondrial Fusion Promoter M1 induces mitochondrial elongation and promotes mitochondrial fusion in mammalian cells.

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技术信息

生物活性

描述Mitochondria are extraordinarily dynamic organelles that have a variety of morphologies, the status of which are controlled by the opposing processes of fission and fusion^[1].Cardiac I/R injury induced brain mitochondrial dynamics imbalance as indicated by reduced mitochondrial fusion proteins expression without alteration in mitochondrial fission, brain mitochondrial dysfunction, BBB breakdown, increased macrophage infiltration, apoptosis, and AD-related proteins. Pretreatment with M1 effectively increased the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduced brain mitochondrial dysfunction, BBB breakdown, macrophage infiltration, apoptosis, and AD-related proteins in rats following cardiac I/R injury^[2].Administration of M1 significantly promoted mitochondrial fusion and attenuated the reduction in optic atrophy 1 (Opa1) expression in diabetic hearts. Importantly, M1 treatment attenuated oxidative stress, improved mitochondrial function and alleviated DCM in diabetic rats. In HG-treated cardiomyocytes, M1 treatment consistently increased the expression of Opa1, promoted mitochondrial fusion, enhanced mitochondrial respiratory capacity and reduced mitochondria-derived superoxide production, all of which were blunted by Opa1 siRNA knockdown. In addition, selective upregulation of Opa1 alone can also promote mitochondrial fusion, improve mitochondrial function and inhibit mitochondria-derived superoxide production in HG-cultured cardiomyocytes^[3].Chronic Mdivi-1, M1, and the combined treatment showed markedly improved cardiac mitochondrial function and dynamic control, leading to a decrease in cardiac arrhythmias, myocardial cell death, and infarct size (49%, 42%, and 51% reduction for HFMdivi1, HFM1, and HFCom, respectively vs HFDV)^[4].
参考文献

[1] Chayodom Maneechote,et al. Modulating mitochondrial dynamics attenuates cardiac ischemia-reperfusion injury in prediabetic rats. Acta Pharmacol Sin. 2021 Mar 12.
[2] Poomarin Surinkaew,et al. Mitochondrial Fusion Promoter Alleviates Brain Damage in Rats with Cardiac Ischemia/Reperfusion Injury.J Alzheimers Dis. 2020;77(3):993-1003.
[3] Mingge Ding,et al. Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way. Acta Physiol (Oxf). 2020 May;229(1):e13428.
[4] Chayodom Maneechote,et al. Chronic Pharmacological Modulation of Mitochondrial Dynamics Alleviates Prediabetes-Induced Myocardial Ischemia-Reperfusion Injury by Preventing Mitochondrial Dysfunction and Programmed Apoptosis. Cardiovasc Drugs Ther. 2021 Sep 13.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7468 mL
- 13.7342 mL
- 27.4685 mL
- 5 mM
- 0.5494 mL
- 2.7468 mL
- 5.4937 mL
- 10 mM
- 0.2747 mL
- 1.3734 mL
- 2.7468 mL

技术信息

CAS号	219315-22-7	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H10Cl4N2O	运输	蓝冰
分子量	364.05	别名	Mitochondrial fusion promoter M1

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Mitochondrial fusion promoter M1/线粒体融合启动子M1 Catalog No. CSN27754

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