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CAS No.: 1354707-41-7

Mitochonic acid 5 Catalog No. CSN21177

Synonyms: MA-5

Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis.

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生物活性

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技术信息

生物活性

描述Mitochondrial dysfunction is involved in the pathogenesis of chronic kidney disease and acute kidney injury (AKI). Mitochonic acid 5 (MA-5) is a synthesized indole acetic acid derivative that facilitates ATP production, reduces the level of mitochondrial reactive oxygen species, and targets mitochondrial protein mitofilin. MA-5 binds to mitofilin with a B_max value of 12.5±4.35ng and a K_d value of 28.2±11.4µM^[1]. MA-5 at 1-10µM dose-dependently inhibited TNFα-induced apoptosis in mouse microglial BV-2 cells. Treatment with MA-5 at 5µM increased mitochondrial potential and decreased the level of mitochondrial calcium in TNFα-treated cells^[2]. In a bilateral ischemia-reperfusion injury (IRI) model, oral administration of MA-5 at 25, 50, or 150mg/kg significantly improved plasma creatinine level after reperfusion compared to the vehicle-treated IRI mice. MA-5 treatment also significantly decreased the expression of AKI marker, KIM-1, at the outer medullar and the acute tubular necrosis score in IRI mice at 48h post-treatment. In a mouse model of cisplatin-induced nephropathy (CIN), MA-5 (50mg/kg)-treated mice showed significantly reduced plasma BUN 96h after cisplatin administration compared to the vehicle-treated CIN animals^[1].
作用机制Mitochonic acid 5 is a synthesized indole derivative that regulates mitochondrial ATP synthesis independently of electron transport chain and oxidative phosphorylation^[1].
参考文献

[1] Suzuki T, Yamaguchi H, Kikusato M, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016;27(7):1925-1932. doi:10.1681/ASN.2015060623
[2] Lei Q, Tan J, Yi S, Wu N, Wang Y, Wu H. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018;23:14.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0368 mL
- 15.1838 mL
- 30.3677 mL
- 5 mM
- 0.6074 mL
- 3.0368 mL
- 6.0735 mL
- 10 mM
- 0.3037 mL
- 1.5184 mL
- 3.0368 mL

技术信息

CAS号

1354707-41-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H13F2NO3

运输

蓝冰

分子量

329.30

别名

MA-5

溶解度

DMSO	25.0 mg/mL (75.9 mM)
Water	Insoluble
Ethanol	Insoluble

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