|3-(顺式-4-((4-氯苯基)磺酰基)-4-(2,5-二氟苯基)环己基)丙酸|CsnPharm

CAS No.: 471905-41-6

MK-0752 Catalog No. CSN13820

Synonyms: MK-0752

MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00106145	Advanced Breast Cancer ... more >> Other Solid Tumors Collapse <<	Phase 1	Completed	-	-
NCT00100152	Leukemia, Lymphoblastic, Acute... more >>, T-cell Myelogenous Leukemia Chronic Lymphocytic Leukemia Myelodysplastic Syndromes Collapse <<	Phase 1	Terminated	-	-
NCT01243762	Neoplasms Malignant	Phase 1	Terminated(The study was termi... more >>nated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.) Collapse <<	-	-

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参考文献

[1] Cook JJ, Wildsmith KR, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010 May 12;30(19):6743-50.
[2] Harrison H, Farnie G, et al. Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res. 2010 Jan 15;70(2):709-18.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2578 mL
- 11.2891 mL
- 22.5783 mL
- 5 mM
- 0.4516 mL
- 2.2578 mL
- 4.5157 mL
- 10 mM
- 0.2258 mL
- 1.1289 mL
- 2.2578 mL

技术信息

CAS号

471905-41-6

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H21ClF2O4S

运输

蓝冰

分子量

442.90

别名

MK-0752

溶解度

DMSO	89.0 mg/mL (200.9 mM)
Water	Insoluble
Ethanol	45.0 mg/mL (101.6 mM)

动物实验配方

30% propylene glycol+5% Tween 80+65% water

30 mg/mL

suspension

大规格询价

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00106145	Advanced Breast Cancer ... more >> Other Solid Tumors Collapse <<	Phase 1	Completed	-	-
NCT00100152	Leukemia, Lymphoblastic, Acute... more >>, T-cell Myelogenous Leukemia Chronic Lymphocytic Leukemia Myelodysplastic Syndromes Collapse <<	Phase 1	Terminated	-	-
NCT01243762	Neoplasms Malignant	Phase 1	Terminated(The study was termi... more >>nated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.) Collapse <<	-	-
NCT00803894	Healthy	Phase 1	Completed	-	-
NCT01098344	Pancreatic Cancer	Phase 1	Completed	-	United Kingdom ... more >> Addenbrooke's Hospital Cambridge, England, United Kingdom, CB2 2QQ Leicester Royal Infirmary Leicester, England, United Kingdom, LE1 5WW Barts and the London School of Medicine London, England, United Kingdom, EC1M 6BQ Beatson West of Scotland Cancer Centre Glasgow, Scotland, United Kingdom, G12 0YN St James' Hospital Leeds, United Kingdom, L59 7TF Collapse <<
NCT00572182	Brain and Central Nervous Syst... more >>em Tumors Collapse <<	Phase 1	Terminated(This Phase I study ... more >>was permanently closed to patient accrual on February 23, 2011, due to the discontinuation of support from MERCK.) Collapse <<	-	United States, California ... more >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010-2970 United States, Illinois Children's Memorial Hospital - Chicago Chicago, Illinois, United States, 60614 United States, Maryland NCI - Pediatric Oncology Branch Bethesda, Maryland, United States, 20892 United States, Massachusetts Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, North Carolina Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104-4318 Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Dan L. Duncan Cancer Center at Baylor College of Medicine Houston, Texas, United States, 77030 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 Collapse <<
NCT01295632	Advanced Cancer	Phase 1	Completed	-	-
NCT00645333	Metastatic Breast Cancer	Phase 1 Phase 2	Completed	-	United States, Massachusetts ... more >> Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Cancer Center Ann Arbor, Michigan, United States, 48109 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Collapse <<
NCT01243762	-	-	Terminated(The study was termi... more >>nated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.) Collapse <<	-	-
NCT00756717	Breast Cancer	Not Applicable	Unknown	May 2018	United States, Illinois ... more >> Loyola Univeristy Medical Center, Cardinal Bernardin Cancer Center Maywood, Illinois, United States, 60153 Collapse <<
NCT00645333	-	-	Completed	-	-

MK-0752 Catalog No. CSN13820

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