CAS No.: 624733-88-6
MK-0812 Catalog No. CSN13664
Synonyms: Mk-0812
MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00239655 Relapsing-Remitting Multiple S... more >>clerosis Collapse << Phase 2 Terminated - - NCT00542022 Arthritis, Rheumatoid Phase 2 Completed - - - 参考文献
- [1] Wisniewski T, Bayne E, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
- [2] Min SH, Wang Y, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 624733-88-6 | 储存条件 |
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| 分子式 | C24H34F3N3O3 | 运输 | 蓝冰 | |
| 分子量 | 469.54 | 别名 | Mk-0812 |
