CAS No.: 1001917-37-8
MK-8033 Catalog No. CSN13613
MK-8033 is a specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00559182 Advanced Cancer Phase 1 Completed - - - 参考文献
- [1] Northrup AB, Katcher MH, et al. Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5] cyclohepta[1,2-b] pyridin-7-yl] -N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. J Med Chem. 2013 Mar 28;56(6):2294-310.
- [2] Bhardwaj V, Zhan Y, et al. C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression. J Thorac Oncol. 2012 Aug;7(8):1211-7.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1001917-37-8 | 储存条件 |
|
|
| 分子式 | C25H21N5O3S | 运输 | 蓝冰 | |
| 分子量 | 471.53 | 别名 |
