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CAS No.: 71203-35-5

ML141 Catalog No. CSN16332

Synonyms: CID-2950007

ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Cdc42

IC50:200nM
描述Cdc42, a member of the Rho family of GTPases, has been shown to play a role in cell adhesion, cytoskeletal arrangement, phagocytosis and cell motility and migration. ML141 is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase with low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7)^[3]. Pharmacological inhibition of Cdc42 with ML141 was similarly effective as genetic knockdown at enabling TMX-induced reductions in levels of EGFR (epidermal growth factor receptor). Co-exposure to 20 µM ML141 (a concentration that selectively inhibits Cdc42 function in BLBC cells) enabled TMX (tamoxifen) to cause a ∼45% reduction in EGFR levels. ML141 exposure also enhanced the ability of TMX to suppress BLBC cell growth, through both induction of cell death and suppression of cell division. Tumour bearing animals were treated with 1 mg/day ML141 and 125 µg/day TMX. Pharmacological inhibition of Cdc42 with ML141 enabled TMX to suppress growth of MDA-MB 231 derived tumours. Moreover, the tumour sizes resulting from ML141 pre-treated cells were markedly smaller than those of the control group^[4]. Moreover, both the absolute numbers of KL (Lin⁻ c-Kit⁺ sca-1⁻) and KSL (Lin⁻ c-Kit⁺ sca-1⁺) population in ML141 treated mice were increased as compared to these in DMSO vehicle control mice. Mice treated with 10 μg ML141 presented higher KL and KSL counts than those in mice with 5 μg ML141^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4541 mL
- 12.2704 mL
- 24.5408 mL
- 5 mM
- 0.4908 mL
- 2.4541 mL
- 4.9082 mL
- 10 mM
- 0.2454 mL
- 1.2270 mL
- 2.4541 mL

技术信息

CAS号

71203-35-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H21N3O3S

运输

蓝冰

分子量

407.49

别名

CID-2950007

溶解度

DMSO	79.0 mg/mL (193.9 mM) warming
Water	Insoluble
Ethanol	Insoluble

动物实验配方

2% DMSO+30% PEG 300+5% Tween 80+water

10 mg/mL

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ML141 Catalog No. CSN16332

靶点选择性

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