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CAS No.: 1210906-48-1

MR837 Catalog No. CSN27839

Synonyms: ZINC-30303842;Z-336955588;NSD2-PWWP1 antagonist 3f

NSD2-PWWP1 antagonist 3f can bind to the NSD2-PWWP1 domain with Kd value of 3.4μM and abrogates histone H3K36me2 binding to the PWWP1 domain in cells.

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描述Epigenetic modifications (or epigenetic tags) on DNA and histones not only alter the chromatin structure, but also provide a recognition platform for subsequent protein recruitment and enable them to acquire executive instructions to carry out specific intracellular biological processes.In cells, different epigenetic-tags on DNA and histones are often recognized by the specific domains in proteins (readers), such as bromodomain (BRD), chromodomain (CHD), plant homeodomain (PHD), Tudor domain, proline-tryptophan-tryptophan-proline (PWWP) domain and malignant brain tumor (MBT) domain^[2].The PWWP domain is a member of the Royal superfamily that functions as a chromatin methylation reader by recognizing both DNA and histone methylated lysines. The PWWP domain three-dimensional structure is based on an N-terminal hydrophobic β-barrel responsible for histone methyl-lysine binding, and a C-terminal α-helical domain^[3]. The PWWP domain interacts with methylated lysine 36 in histone H3, a marker of actively transcribed genes^[4]. PWWP domains possess a conserved aromatic cage for histone methyl-lysine recognition, and synergistically bind both histone and DNA, which contributes to their nucleosome-binding ability and chromatin localization. Furthermore, the PWWP domain often cooperates with other histone and DNA 'reader' or 'modifier' domains to evoke crosstalk between various epigenetic marks^[5].MR837 is an inhibitor of NSD2-PWWP1. MR837 can bind with human nuclear receptor binding SET domain protein 2 (PWWP domain)^[1].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5416 mL
- 17.7079 mL
- 35.4158 mL
- 5 mM
- 0.7083 mL
- 3.5416 mL
- 7.0832 mL
- 10 mM
- 0.3542 mL
- 1.7708 mL
- 3.5416 mL

技术信息

CAS号	1210906-48-1	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H14N2OS	运输	蓝冰
分子量	282.36	别名	ZINC-30303842;Z-336955588;NSD2-PWWP1 antagonist 3f

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MR837 Catalog No. CSN27839

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