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CAS No.: 607-91-0

Myristicin/肉豆蔻醚 Catalog No. CSN20978

Synonyms: Myristicine;HSDB-3516;肉豆蔻醚

Myristicin is a natural product found in spices and umbelliferous plants. It induces apoptosis in leukemia cells, decreases pro-inflammatory cytokine expression in alveolar epithelial cells, and suppresses growth of Clostridium, Enterococcus, Candida.

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400-920-2911

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技术信息

生物活性

描述Myristicine act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt^[1]. Myristicin did not reduce the cell viability of RAW 264.7 mouse macrophages at concentrations of up to 50 μM. Myristicin significantly inhibited the production of calcium, nitric oxide (NO),interleukin (IL)-6, IL-10, interferon inducible protein-10, monocyte chemotactic protein(MCP)-1, MCP-3, granulocyte-macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1α, MIP-1β, and leukemia inhibitory factor in dsRNA[polyinosinic-polycytidylic acid]-induced RAW 264.7 cells^[2]. Myristicin inhibited cell proliferation and induced apoptosis in Huh-7 and HCCLM3 cells; suppressed cell migration and invasion ability, and increased E-cadherin expression and decreased N-cadherin expression, thereby inhibiting epithelial-mesenchymal transition (EMT). Myristicin decreased phosphorylated p-mTOR and p-AKT expression at the protein level^[3].
参考文献

[1] Kalbhen DA. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans). Angew Chem Int Ed Engl. 1971 Jun;10(6):370-4
[2] Lee JY, Park W. Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid. Molecules. 2011;16(8):7132-42
[3] Bao H, Muge Q. Anticancer effect of myristicin on hepatic carcinoma and related molecular mechanism. Pharm Biol. 2021 Dec;59(1):1126-1132

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2026 mL
- 26.0132 mL
- 52.0264 mL
- 5 mM
- 1.0405 mL
- 5.2026 mL
- 10.4053 mL
- 10 mM
- 0.5203 mL
- 2.6013 mL
- 5.2026 mL

技术信息

CAS号	607-91-0	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C11H12O3	运输	蓝冰
分子量	192.21	别名	Myristicine;HSDB-3516;肉豆蔻醚

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