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CAS No.: 118876-58-7

NBQX Catalog No. CSN22241

Synonyms: FG9202

NBQX is a potent, selective and competitive AMPAR antagonist, which shows activity of neuroprotective and anticonvulsant.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The hippocampus is an important brain region that is involved in neurological disorders such as Alzheimer disease, schizophrenia, and epilepsy. Ionotropic glutamate receptors—namely, N-methyl-D-aspartate (NMDA) receptors (NMDARs), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs), and kainic acid (KA) receptors (KARs)—are well known to be involved in these diseases by mediating long-term potentiation, excitotoxicity, or both. NBQX is an antagonist of AMPARs and KARs. NBQX for AMPA and KA stimulation (IC₅₀ = 0.7 ± 0.1 and 0.7 ± 0.03 μM, respectively; n = 3). The effects of NBQX on the AMPA- or KA-evoked calcium rise in differentiated HIP-009 cells were assessed. NBQX inhibited both AMPA- and KA-induced signals in a concentration-dependent fashion (IC₅₀ = 0.7 ± 0.1 and 0.7 ± 0.03 μM for AMPA and KA stimulation, respectively, n = 3). The AMPA-evoked calcium rise was completely inhibited by NBQX, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX treatment. The effect of co-treatment with MK-801 (a NMDAR antagonist) and NBQX on the glutamate-evoked calcium rise was assessed. When 30 μM of MK-801 or NBQX was added alone, 44.5% ± 2.2% or 34.2% ± 5.0%, respectively, of the glutamate-induced calcium rise was inhibited. Co-treatment had an additive inhibitory effect on total calcium rise upon glutamate stimulation (78.6% ± 2.2% inhibition)^[1].
参考文献

[1] Fukushima K, Tabata Y, Imaizumi Y, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014;19(8):1174-1184.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9737 mL
- 14.8686 mL
- 29.7371 mL
- 5 mM
- 0.5947 mL
- 2.9737 mL
- 5.9474 mL
- 10 mM
- 0.2974 mL
- 1.4869 mL
- 2.9737 mL

技术信息

CAS号

118876-58-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H8N4O6S

运输

蓝冰

分子量

336.28

别名

FG9202

溶解度

DMSO	92.0 mg/mL (273.6 mM) warming
Water	insoluble

动物实验配方

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