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CAS No.: 209410-46-8
Synonyms: VRT-031745;VD-31745;VX-745
VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
规格 | 价格 | 促销价格 | 库存 | 数量 |
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生物活性
靶点 | p38 MAPKα IC50:10nM |
动物研究 | |||||||||||||||||||||||||||||||||||||
剂量 | Rat: 0.5 mg/kg - 4.5 mg/kg[3] (p.o.), 5 mg/kg - 50 mg/kg[4] (p.o.) Mice: 2.5 mg/kg - 10 mg/kg[1] (p.o.) | ||||||||||||||||||||||||||||||||||||
给药途径 | p.o. | ||||||||||||||||||||||||||||||||||||
动物药代数据 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03402659 | Alzheimer Disease | Phase 2 | Recruiting | July 31, 2019 | - |
NCT02423200 | Alzheimer's Disease | Phase 2 | Completed | - | United States, California ... more >> Parexel International Glendale, California, United States, 91206 Collapse << |
NCT03435861 | Alzheimer Disease | Phase 2 | Recruiting | January 30, 2021 | France ... more >> CHU Toulouse Recruiting Toulouse, France, 31000 Contact: Jeremie Pariente, Pr Collapse << |
实验方案
技术信息
CAS号 | 209410-46-8 | 储存条件 |
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分子式 | C19H9Cl2F2N3OS | 运输 | 蓝冰 | |||||||||||
分子量 | 436.26 | 别名 | VRT-031745;VD-31745;VX-745 | |||||||||||
溶解度 |
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动物实验配方 |
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