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CAS No.: 1254036-71-9
Synonyms: GSK2269557 (free base);GSK-2269557 Free Base;GSK-2269557
GSK-2269557 has low oral bioavailability (F=2%) and in vivo clearance of 28 mL/min/kg but has a high volume of distribution of 6.3 L/kg.
生物活性
靶点 | PI3Kδ pKi:9.9 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01462617 | Asthma | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site London, United Kingdom, SE1 1YR Collapse << |
NCT03345407 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 2 | Active, not recruiting | January 10, 2019 | - |
NCT02130635 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 2 | Completed | - | Germany ... more >> GSK Investigational Site Grosshansdorf, Schleswig-Holstein, Germany, 22927 GSK Investigational Site Berlin, Germany, 14050 Collapse << |
实验方案
技术信息
CAS号 | 1254036-71-9 | 储存条件 |
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分子式 | C26H28N6O | 运输 | 蓝冰 | |
分子量 | 440.54 | 别名 | GSK2269557 (free base);GSK-2269557 Free Base;GSK-2269557;GSK2269557 (free base |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01462617 | Asthma | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site London, United Kingdom, SE1 1YR Collapse << |
NCT03345407 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 2 | Active, not recruiting | January 10, 2019 | - |
NCT02130635 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 2 | Completed | - | Germany ... more >> GSK Investigational Site Grosshansdorf, Schleswig-Holstein, Germany, 22927 GSK Investigational Site Berlin, Germany, 14050 Collapse << |
NCT02130635 | - | - | Completed | - | - |
NCT02691325 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> GSK Investigational Site Baltimore, Maryland, United States, 21225 Collapse << |
NCT01762878 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site London, United Kingdom, NW10 7EW Collapse << |
NCT02972905 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 1 | Completed | - | Japan ... more >> GSK Investigational Site Fukuoka, Japan, 813-0017 Collapse << |
NCT02567708 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 2 | Completed | - | Germany ... more >> GSK Investigational Site Muenchen, Bayern, Germany, 80539 GSK Investigational Site Ruedersdorf, Brandenburg, Germany, 15562 GSK Investigational Site Frankfurt, Hessen, Germany, 60389 GSK Investigational Site Frankfurt, Hessen, Germany, 60596 GSK Investigational Site Homburg, Saarland, Germany, 66421 GSK Investigational Site Leipzig, Sachsen, Germany, 04275 GSK Investigational Site Leipzig, Sachsen, Germany, 04357 GSK Investigational Site Luebeck, Schleswig-Holstein, Germany, 23552 GSK Investigational Site Berlin, Germany, 10119 GSK Investigational Site Berlin, Germany, 10717 GSK Investigational Site Berlin, Germany, 10787 GSK Investigational Site Magdeburg, Germany, 39120 Collapse << |
NCT02294734 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 2 | Completed | - | Belgium ... more >> GSK Investigational Site Edegem, Belgium, 2650 GSK Investigational Site Erpent, Belgium, 5101 Denmark GSK Investigational Site Aalborg, Denmark, DK-9100 GSK Investigational Site Hellerup, Denmark, 2900 GSK Investigational Site Hvidovre, Denmark, 2650 GSK Investigational Site Kobenhavn, Denmark, DK-2400 GSK Investigational Site Odense, Denmark, 5000 Odense C Netherlands GSK Investigational Site Almelo, Netherlands, 7609 PP GSK Investigational Site Eindhoven, Netherlands, 5623 EJ GSK Investigational Site Zutphen, Netherlands, 7207 AE Romania GSK Investigational Site Bucharest, Romania, 050159 GSK Investigational Site Timisoara, Romania, 300310 Russian Federation GSK Investigational Site Ekaterinburg, Russian Federation, 620109 GSK Investigational Site Kemerovo, Russian Federation, 650002 GSK Investigational Site Moscow, Russian Federation, 105 077 GSK Investigational Site Saint Petersburg, Russian Federation, 194291 GSK Investigational Site Vladimir, Russian Federation, 600023 GSK Investigational Site Yaroslavl, Russian Federation, 150003 Collapse << |
NCT03315559 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site London, United Kingdom, NW10 7EW Collapse << |
NCT02593539 | Activated PI3K-delta Syndrome | Phase 2 | Recruiting | December 11, 2019 | United Kingdom ... more >> GSK Investigational Site Recruiting Cambridge, United Kingdom, CB2 0GG Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com Collapse << |
NCT03189589 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site Cambridge, United Kingdom, CB2 0GG Collapse << |
NCT02294734 | - | - | Completed | - | - |
NCT02522299 | Pulmonary Disease, Chronic Obs... more >>tructive Collapse << | Phase 2 | Completed | - | Canada, British Columbia ... more >> GSK Investigational Site Vancouver, British Columbia, Canada, V5Z 1M9 GSK Investigational Site Vancouver, British Columbia, Canada, V6Z 1Y6 Canada, Ontario GSK Investigational Site Hamilton, Ontario, Canada, L8N 3Z5 GSK Investigational Site Montreal, Ontario, Canada, H4A 3J1 Canada, Quebec GSK Investigational Site Montreal, Quebec, Canada, H2W1T8 Canada GSK Investigational Site Quebec, Canada, G1V 4G5 Denmark GSK Investigational Site Odense, Denmark, DK-5000 Collapse << |
NCT02567708 | - | - | Completed | - | - |
靶点 | Description | IC50 |
---|---|---|
PI3Kδ | pKi:9.9 |
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