|(3S,6S,7R,7aR,8S,9S,10S,11aR,12R,12aR,13R,14R)-1-乙基-10,13-二甲氧基-3-(甲氧基甲基)十四氢-1H-3,6a,12-(epiethane[1,1,2]三基)-7,9-甲萘[2,3-b]氮杂环辛四烯-6,8,11a-三醇|CsnPharm

CAS No.: 466-26-2

Neoline/雪上一枝蒿乙素 Catalog No. CSN16360

Synonyms: Bullatine B;Dideacetyldelphisine;雪上一枝蒿乙素

Bullatine B is a natural product isolated and purified from the roots of Aconitum brachypodum Diels.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Bullatine B (Neoline) is a natural product isolated and purified from the roots of Aconitum brachypodum Diels. Neoline significantly attenuated the mechanical hyperalgesia induced by either paclitaxel or partial ligation of the sciatic nerve in mice. Neoline can be used as a marker compound to determine the quality of the PA (Processed aconite root) products for the treatment of neuropathic pain^[1]. Neoline inhibited the production of 3'-p-hydroxypaclitaxel at 50 μM, but not at lower concentrations^[2].
参考文献

[1] Tanimura Y, Yoshida M, Ishiuchi K, Ohsawa M, Makino T. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats. J Ethnopharmacol. 2019 Sep 15;241:111859
[2] Nakayama A, Tsuchiya K, Xu L, Matsumoto T, Makino T. Drug-interaction between paclitaxel and goshajinkigan extract and its constituents. J Nat Med. 2022 Jan;76(1):59-67

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2854 mL
- 11.4268 mL
- 22.8535 mL
- 5 mM
- 0.4571 mL
- 2.2854 mL
- 4.5707 mL
- 10 mM
- 0.2285 mL
- 1.1427 mL
- 2.2854 mL

技术信息

CAS号

466-26-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H39NO6

运输

蓝冰

分子量

437.57

别名

Bullatine B;Dideacetyldelphisine;雪上一枝蒿乙素;尼奥林

溶解度

DMSO	240.0 mg/mL (548.5 mM) warming

动物实验配方

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