CAS No.: 915942-22-2
Neratinib maleate Catalog No. CSN20576
Synonyms: HKI-272 maleate;HKI-272;PB-272
Neratinib maleate is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Awada A, Colomer R, et al. Neratinib Plus Paclitaxel vs Trastuzumab Plus Paclitaxel in Previously Untreated Metastatic ERBB2-Positive Breast Cancer: The NEfERT-T Randomized Clinical Trial. JAMA Oncol. 2016 Dec 1;2(12):1557-1564.
- [2] Rabindran SK, Discafani CM, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 2004 Jun 1;64(11):3958-65.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 915942-22-2 | 储存条件 |
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| 分子式 | C34H33ClN6O7 | 运输 | 蓝冰 | |
| 分子量 | 673.11 | 别名 | HKI-272 maleate;HKI-272;PB-272;Neratinib;Nerlynx |
