生物活性

• 描述Nilutamide is a synthetic, non-steroidal antiandrogen (NSAA) used in the treatment of advanced-stage (metastatic) prostate cancer.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00003653	Prostate Cancer	Phase 3	Completed	-	Canada, Alberta ... more >> Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2 Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia BCCA - Cancer Centre for the Southern Interior Kelowna, British Columbia, Canada, V1Y 5L3 BCCA - Fraser Valley Cancer Centre Surrey, British Columbia, Canada, V3V 1Z2 Clinical Research Unit at Vancouver Coastal Vancouver, British Columbia, Canada, V5Z 1M9 BCCA - Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Manitoba CancerCare Manitoba Winnipeg, Manitoba, Canada, R3E 0V9 Canada, New Brunswick The Vitalite Health Network - Dr. Leon Richard Moncton, New Brunswick, Canada, E1C 8X3 Atlantic Health Sciences Corporation Saint John, New Brunswick, Canada, E2L 4L2 Canada, Newfoundland and Labrador Dr. H. Bliss Murphy Cancer Centre St. John's, Newfoundland and Labrador, Canada, AIB 3V6 Canada, Nova Scotia QEII Health Sciences Center Halifax, Nova Scotia, Canada, B3H 1V7 Canada, Ontario William Osler Health Centre, Brampton Memorial Brampton, Ontario, Canada, L6R 3J7 Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 Cancer Centre of Southeastern Ontario at Kingston Kingston, Ontario, Canada, K7L 5P9 London Regional Cancer Program London, Ontario, Canada, N6A 4L6 Credit Valley Hospital Mississauga, Ontario, Canada, L5M 2N1 Ottawa Health Research Institute - General Division Ottawa, Ontario, Canada, K1H 8L6 Niagara Health System St. Catharines, Ontario, Canada, L2R 7C6 Northeast Cancer Center Health Sciences Sudbury, Ontario, Canada, P3E 5J1 Thunder Bay Regional Health Science Centre Thunder Bay, Ontario, Canada, P7B 6V4 Odette Cancer Centre Toronto, Ontario, Canada, M4N 3M5 Univ. Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Windsor Regional Cancer Centre Windsor, Ontario, Canada, N8W 2X3 Canada, Quebec CHUM - Hopital Notre-Dame Montreal, Quebec, Canada, H2L 4M1 McGill University - Dept. Oncology Montreal, Quebec, Canada, H2W 1S6 CHUQ-Pavillon Hotel-Dieu de Quebec Quebec City, Quebec, Canada, G1R 2J6 Centre hospitalier universitaire de Sherbrooke Sherbrooke, Quebec, Canada, J1H 5N4 Canada, Saskatchewan Allan Blair Cancer Centre Regina, Saskatchewan, Canada, S4T 7T1 Saskatoon Cancer Centre Saskatoon, Saskatchewan, Canada, S7N 4H4 Collapse <<
  NCT02376296	-	-	Recruiting	December 2019	United States, Pennsylvania ... more >> UPMC CancerCenter - Beaver Recruiting Beaver, Pennsylvania, United States, 15009 Contact: Karen Flanagan    724-371-3852    flanagankd@upmc.edu    Sub-Investigator: William Ferri, MD          Sub-Investigator: Stewart Lancaster, MD          Sub-Investigator: Grace R Tarabay, MD          UPMC CancerCenter - Upper St. Clair Recruiting Bethel Park, Pennsylvania, United States, 15102 Contact: Rita Pfrimmer    412-831-7096    pfrimmerra@upmc.edu    Sub-Investigator: Ronald Fierro, MD          Sub-Investigator: Vincent E Reyes, Jr., MD          Sub-Investigator: Robert VanderWeele, MD          Sub-Investigator: Robert Volkin, MD          UPMC CancerCenter - Horizon Recruiting Farrell, Pennsylvania, United States, 16121 Contact: Kristy Thompson    814-676-7881    thompsonk15@upmc.edu    Sub-Investigator: William Spielvogel, MD          Arnold Palmer Cancer Center - Oakbrook Recruiting Greensburg, Pennsylvania, United States, 15601 Contact: Diane Trout    724-834-1463 ext 119    troutdl@upmc.edu    Sub-Investigator: Hyoung Kim, MD          Sub-Investigator: John Waas, DO          Arnold Palmer Cancer Center Recruiting Greensburg, Pennsylvania, United States, 15601 Contact: Amy Alfery    724-838-5693    alferyas@upmc.edu    Sub-Investigator: Terry Evans, MD          Sub-Investigator: Gauri Kiefer, MD          Sub-Investigator: Rajesh Sehgal, MD          Sub-Investigator: Matthew Sulecki, MD          Sub-Investigator: Franklin Viverette, MD          UPMC CancerCenter - Greenville Recruiting Greenville, Pennsylvania, United States, 16125 Contact: Kristy Thompson    814-676-7881    thompsonk15@upmc.edu    Sub-Investigator: Edgardo Lob, MD          UPMC CancerCenter - Indiana Recruiting Indiana, Pennsylvania, United States, 15701 Contact: Judy Sosko    814-534-2887    soskoj@upmc.edu    Sub-Investigator: Gopala Ramineni, MD          Sub-Investigator: Michael Voloshin, MD          UPMC CancerCenter at John P. Murtha Regional Cancer Center Recruiting Johnstown, Pennsylvania, United States, 15901 Contact: Judy Sosko    814-533-0106    soskoj@upmc.edu    Sub-Investigator: Rashid Awan, MD          Sub-Investigator: Michael Voloshin, MD          UPMC CancerCenter - Mckeesport Recruiting McKeesport, Pennsylvania, United States, 15132 Contact: Anita Doyle    412-653-8103    doylea2@upmc.edu    Sub-Investigator: Jason Bierenbaum, MD          Sub-Investigator: Kevin Kane, MD          UPMC CancerCenter - Monroeville Recruiting Monroeville, Pennsylvania, United States, 15146 Contact: Michelle Zaspel    412-374-1441    zaspma@upmc.edu    Sub-Investigator: Hyoung Kim, MD, FACP          Sub-Investigator: John Lech, DO          Sub-Investigator: Dhaval Mehta, MD          Sub-Investigator: John Morcos, MD          Sub-Investigator: Rajesh Sehgal, MD          Arnold Palmer Medical Oncology - Mount Pleasant Recruiting Mount Pleasant, Pennsylvania, United States, 15666 Contact: Diane Trout    724-834-1463 ext 119    troutdl@upmc.edu    Sub-Investigator: Hyoung Kim, MD          Sub-Investigator: John P Morcos, MD          UPMC CancerCenter - New Castle Recruiting New Castle, Pennsylvania, United States, 16105 Contact: Karen Flanagan    724-658-0853 ext 107    flanagankd@upmc.edu    Sub-Investigator: Sheryl Simon, MD          Sub-Investigator: William Spielvogel, MD          UPMC CancerCenter - St. Margaret Recruiting Pittsburgh, Pennsylvania, United States, 15215 Contact: Cathy Van Every    412-781-3744    vaneverycc@upmc.edu    Sub-Investigator: Peter Ellis, MD          Sub-Investigator: Mark Georgiadis, MD          Sub-Investigator: Hongmei Liang, MD          Sub-Investigator: Min Sun, MD          UPMC CancerCenter - Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Bethany Flaherty    412-623-8962    schnelbachb@upmc.edu    Contact: Kristyn Miller    412-647-8475    millerkm3@upmc.edu    Principal Investigator: Leonard J Appleman, MD, PhD          Sub-Investigator: Lanie K Francis, MD          Sub-Investigator: David M Friedland, MD          Sub-Investigator: Barry C Lembesky, MD          Sub-Investigator: Stanley M Marks, MD          Sub-Investigator: James P Ohr, DO          Sub-Investigator: Rahul A Parikh, MD, PhD          Sub-Investigator: Daniel P Petro, MD          Sub-Investigator: John C Rhee, MD          Sub-Investigator: Ronald G Stroller, MD          UPMC CancerCenter - Passavant HOA Recruiting Pittsburgh, Pennsylvania, United States, 15237 Contact: Melissa Jackson    412-748-6027    jacksonm12@upmc.edu    Sub-Investigator: Jennifer Osborn, MD          UPMC CancerCenter - Passavant OHA Recruiting Pittsburgh, Pennsylvania, United States, 15237 Contact: Melissa Jackson    412-748-6027    jacksonm12@upmc.edu    Sub-Investigator: Theodore Crandall, MD          Sub-Investigator: Robert Gluckman, MD          Sub-Investigator: Brian McLaughlin, MD          Sub-Investigator: Kiran Rajasenan, MD          UPMC CancerCenter - Northwest Recruiting Seneca, Pennsylvania, United States, 16346 Contact: Kristy Thompson    814-676-7881    thompsonk15@upmc.edu    Sub-Investigator: Cindylou Connell, MD          Sub-Investigator: Donna Puleio, MD          UPMC CancerCenter - Uniontown Recruiting Uniontown, Pennsylvania, United States, 15401 Contact: Harry Strauser    724-439-8950 ext 126    strauserhj@upmc.edu    Sub-Investigator: Afaq Ahmad, MD          Sub-Investigator: Lijun Dai, MD          Sub-Investigator: Sajid M Peracha, MD          UPMC CancerCenter - Washington Recruiting Washington, Pennsylvania, United States, 15301 Contact: Elizabeth Goddard    724-223-3816    goddardea@upmc.edu    Sub-Investigator: Patrick Kane, MD          Sub-Investigator: Nitin Kapoor, DO          Sub-Investigator: Alexis Megaludis, MD          UPMC CancerCenter - Jefferson Recruiting West Mifflin, Pennsylvania, United States, 15122 Contact: Anita Doyle    412-653-8103    doylea2@upmc.edu    Sub-Investigator: Martin Earle, MD          Sub-Investigator: Andrew Laman, MD Collapse <<
  NCT03678025	Castration Levels of Testoster... more >>one Metastatic Prostatic Adenocarcinoma Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8 Collapse <<	Phase 3	Recruiting	October 1, 2031	United States, Texas ... more >> MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Brian Chapin, MD Collapse <<

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• 参考文献

• [1] Wellington K, Keam SJ. Bicalutamide 150mg: a review of its use in the treatment of locally advanced prostate cancer. Drugs. 2006;66(6):837-50.Erratum in: Drugs. 2006;66(15):1987.

  [2] Saunders MJ, Kim H, et al. Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry A. 2006 May;69(5):342-52.