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CAS No.: 88206-46-6

Notopterol/羌活醇 Catalog No. CSN13525

Synonyms: 羌活醇

Notopterol induces apoptosis and inhibits cell cycle-specific, it's a natural product isolated and purified from the roots of Notopterygium incisum.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Notopterol (NOT) is a major bioactive ingredient extracted from the rhizomes of either Notopterygium incisum Ting ex H. T. Chang or N. forbesii Boiss (Qianghuo in Chinese), a botanical drug that was adopted as a traditional Chinese medicine. NOT inhibited the activity of CYP2D6 in a time-, concentration- and NADPH-dependent manner. The values of KI and kinact were 10.8 μM and 0.62 min-1, respectively^[3]. Notopterol induces apoptosis and inhibits cell cycle-specific, it's a natural product isolated and purified from the roots of Notopterygium incisum. Notopterol could induce apoptosis, differentiation, and G0/G1 arrest in human AML HL-60 cells, suggesting that notopterol has potential therapeutic effects on AML. The combination application of notopterol (20 and 40 μM) and ATRA (2 μM) could augment differentiation of HL-60 cells^[4]. Mechanistically, notopterol directly binds Janus kinase (JAK)2 and JAK3 kinase domains to inhibit JAK/signal transducers and activators of transcription (JAK-STAT) activation, leading to reduced production of inflammatory cytokines and chemokines^[5]. NOT could arrest osteoclastogenesis and bone resorptive activity by attenuating RANKL-mediated MAPK, NF-κB, calcium and NFATc1 signaling transduction pathways and enhancing ROS scavenging enzymes in Nrf2/Keap1/ARE pathways in vitro, and prohibit bone loss induced by OVX in vivo^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8217 mL
- 14.1085 mL
- 28.2170 mL
- 5 mM
- 0.5643 mL
- 2.8217 mL
- 5.6434 mL
- 10 mM
- 0.2822 mL
- 1.4108 mL
- 2.8217 mL

技术信息

CAS号

88206-46-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22O5

运输

蓝冰

分子量

354.40

别名

羌活醇

溶解度

DMSO	70.0 mg/mL (197.5 mM)

动物实验配方

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