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CAS No.: 475489-16-8
Synonyms: AEW541
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM, 27-fold greater selectivity for IGF-1R than InsR.
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技术信息
CAS号 | 475489-16-8 | 储存条件 |
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分子式 | C27H29N5O | 运输 | 蓝冰 | |
分子量 | 439.55 | 别名 | AEW541 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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32D-Bcr-Abl | ~10 μM | Kinase assay | - | inhibits Bcr-Abl p210 with IC50 of >10 μM | 15050915 |
6647 | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
A14 | ~10 μM | Kinase assay | - | inhibits InsR with IC50 of 2.3 ± 0.163 μM | 15050915 |
A31 | ~10 μM | Kinase assay | - | inhibits PDGFR with IC50 of >10 μM | 15050915 |
A431 | ~10 μM | Kinase assay | - | inhibits HER1 with IC50 of >10 μM | 15050915 |
BON | ~6 μM | Kinase assay | - | induces dephosphorylation of IGF-1R | 16601284 |
BON | ~10 μM | Growth inhibitory assay | - | IC50=6.6 μM | 16601284 |
BON | ~7.5 μM | Function assay | - | induces cell cycle arrest | 16601284 |
BON | ~7.5 μM | Apoptosis assay | - | induces Apoptosis | 16601284 |
CCA | ~7 μM | Growth inhibitory assay | - | IC50<2 μM | 15867386 |
CC-LP-1 | ~250 nM | Growth inhibitory assay | - | IC50=0.15 μM | 20066734 |
CC-SW-1 | ~250 nM | Growth inhibitory assay | - | IC50=0.54 μM | 20066734 |
CM | ~5 μM | Growth inhibitory assay | - | IC50=3.3 μM | 16601284 |
CM | ~5 μM | Function assay | - | induces cell cycle arrest | 16601284 |
CM | ~5 μM | Apoptosis assay | - | induces Apoptosis | 16601284 |
ECC-1 | ~10 μM | Kinase assay | - | inhibits IGF-IR activation by 98% | 21295335 |
ECC-1 | ~10 μM | Growth inhibitory assay | - | decreases cell proliferation | 21295335 |
EGI-1 | ~250 nM | Growth inhibitory assay | - | IC50=0.28 μM | 20066734 |
GI-CA-N | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
GI-CA-N | ~8 μM | Growth inhibitory assay | - | IC50= 6.8 μM | 17121898 |
GI-CA-N | ~8 μM | Apoptosis assay | - | induces apoptosis | 17121898 |
GIST882 | ~10 μM | Kinase assay | - | inhibits c-Kit with IC50 of >5 μM | 15050915 |
HCT-116 | ~10 μM | Growth inhibitory assay | - | IC50=2.5 μM | 17007015 |
Hep-3B | ~10 μM | Growth inhibitory assay | - | IC50=1.9 μM | 16530734 |
Hep-G2 | ~10 μM | Growth inhibitory assay | - | IC50=1.8 μM | 16530734 |
Hep-G2 | ~10 μM | Function assay | - | Induces cell cycle arrest | 16530734 |
HL60AR | 160 nM | Function assay | - | enhances the levels of p27Kip1 | 17361225 |
HL60AR | ~200 nM | Apoptosis assay | - | induces apoptosis | 17361225 |
HPAF-II | ~1 μM | Kinase assay | - | inhibits IGF-I-mediated signalling | 18445520 |
HPAF-II | ~2 μM | Growth inhibitory assay | - | inhibits cell proliferation | 18445520 |
HPAF-II | ~2 μM | Function assay | - | inhibits basal and IGF-I-mediated pancreatic cancer cell migration | 18445520 |
HT-29 | ~10 μM | Growth inhibitory assay | - | IC50=1.7 μM | 17007015 |
HTLA-230 | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
HTLA-230 | ~8 μM | Growth inhibitory assay | - | IC50= 0.5 μM | 17121898 |
HTLA-230 | ~8 μM | Apoptosis assay | - | induces apoptosis | 17121898 |
Huh-7 | ~10 μM | Growth inhibitory assay | - | IC50=1.4 μM | 16530734 |
Huh-7 | ~10 μM | Function assay | - | Induces cell cycle arrest | 16530734 |
IOR/BRZ | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
IOR/CAR | ~7 μM | Growth inhibitory assay | - | IC50<1 μM | 15867386 |
IOR/NGR | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
IOR/OS10 | ~7 μM | Growth inhibitory assay | - | IC50<5 μM | 15867386 |
IOR/OS14 | ~7 μM | Growth inhibitory assay | - | IC50<4 μM | 15867386 |
IOR/OS7 | ~7 μM | Growth inhibitory assay | - | IC50<1 μM | 15867386 |
IOR/OS9 | ~7 μM | Growth inhibitory assay | - | IC50<6 μM | 15867386 |
IOR/RCH | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
Ishikawa | ~10 μM | Kinase assay | - | inhibits IGF-IR activation by 93% | 21295335 |
Ishikawa | ~10 μM | Growth inhibitory assay | - | decreases cell proliferation | 21295335 |
KCNR | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
KCNR | ~8 μM | Growth inhibitory assay | - | IC50= 0.4 μM | 17121898 |
KCNR | ~8 μM | Apoptosis assay | - | induces apoptosis | 17121898 |
LAN-5 | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
LAN-5 | ~8 μM | Growth inhibitory assay | - | IC50= 0.4 μM | 17121898 |
LAP35 | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
MCF-7 | - | Cytoxicity assay | - | IC50=1.64 μM | 15050915 |
MOS | ~7 μM | Growth inhibitory assay | - | IC50<4 μM | 15867386 |
Mz-ChA-1 | ~250 nM | Growth inhibitory assay | - | IC50=1.39 μM | 20066734 |
Mz-ChA-2 | ~250 nM | Growth inhibitory assay | - | IC50=0.73 μM | 20066734 |
NWT-21 | ~10 μM | Kinase assay | - | inhibits IGF-IR with IC50 of 0.086 ± 0.028 μM | 15050915 |
NWT-21 | - | Growth inhibitory assay | - | IC50=0.163 μM | 15050915 |
OVCAR-3 | ~15 μM | Growth inhibitory assay | - | inhibits cell proliferation | 16300820 |
OVCAR-3 | ~15 μM | Apoptosis assay | - | induces apoptosis | 16300820 |
OVCAR-3 | ~15 μM | Function assay | - | Decreases phosphorylation of AKT | 16300820 |
OVCAR-4 | ~15 μM | Growth inhibitory assay | - | inhibits cell proliferation | 16300820 |
OVCAR-4 | ~15 μM | Apoptosis assay | - | induces apoptosis | 16300820 |
primary colorectal cancer cells | ~5 μM | Function assay | - | alters the morphology of the remaining cells | 17007015 |
RD/18 | ~7 μM | Growth inhibitory assay | - | IC50<4 μM | 15867386 |
RD-ES | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
RMZ-RC2 | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
RN-GA | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
RN-GA | ~8 μM | Growth inhibitory assay | - | IC50= 1.3 μM | 17121898 |
Saos-2 | ~7 μM | Growth inhibitory assay | - | IC50<3 μM | 15867386 |
SARG | ~7 μM | Growth inhibitory assay | - | IC50<3 μM | 15867386 |
SH-EP | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
SH-EP | ~8 μM | Growth inhibitory assay | - | IC50= 3 μM | 17121898 |
SJ-Rh 30 | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
SJ-Rh 4 | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
Sk-ChA-1 | ~250 nM | Growth inhibitory assay | - | IC50=0.2 μM | 20066734 |
SK-ES-1 | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
SK-Hep-1 | ~10 μM | Growth inhibitory assay | - | IC50=6.9 μM | 16530734 |
SK-Hep-1 | ~10 μM | Function assay | - | Induces cell cycle arrest | 16530734 |
SK-N-AS | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
SK-N-AS | ~8 μM | Growth inhibitory assay | - | induces apoptosis | 17121898 |
SK-N-BE | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
SK-N-BE2 | ~8 μM | Growth inhibitory assay | - | IC50= 3 μM | 17121898 |
SK-N-BE2c | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
SK-N-BE2c | ~8 μM | Growth inhibitory assay | - | IC50= 1.1 μM | 17121898 |
SK-N-BE2c | ~8 μM | Apoptosis assay | - | induces apoptosis | 17121898 |
SK-N-MC | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
SY-5Y (N) | ~8 μM | Growth inhibitory assay | - | IC50= 2.4 μM | 17121898 |
SY-5Y (N) | ~8 μM | Apoptosis assay | - | induces apoptosis | 17121898 |
SY-5Y(N) | ~8 μM | Function assay | - | inhibits IGF-II-mediated stimulation of IGF-IR and Akt | 17121898 |
TC-71 | ~1 μM | Growth inhibitory assay | - | inhibits insulin-like growth factor-I–mediated growth | 15867386 |
TC-71 | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
TFK-1 | ~250 nM | Growth inhibitory assay | - | IC50=0.26 μM | 20066734 |
U-2OS | ~7 μM | Growth inhibitory assay | - | IC50<0.5 μM | 15867386 |
USPC-1 | ~10 μM | Kinase assay | - | inhibits IGF-IR activation by 100% | 21295335 |
USPC-1 | ~10 μM | Growth inhibitory assay | - | decreases cell proliferation | 21295335 |
USPC-2 | ~10 μM | Kinase assay | - | inhibits IGF-IR activation by 96% | 21295335 |
USPC-2 | ~10 μM | Growth inhibitory assay | - | decreases cell proliferation | 21295335 |
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