|(1S,3aS,4aR,4bR,6aR,11aR,11bR,13aS)-1-(呋喃-3-基)-4b,7,7,11a,13a-五甲基-6,6a,7,11a,11b,12,13,13a-八氢氧杂卓并[4',3'：3,4]苯并[1,2-f]环氧乙烷[2,3-d]异苯并吡喃-3,5,9(1H,3aH,4bH)-三酮|CsnPharm

CAS No.: 751-03-1

Obacunone/黄柏酮 Catalog No. CSN15677

Synonyms: AI3-37934;CCRIS 8657;黄柏酮

Obacunone, a natural product isolated and purified from the barks of Phellodendron chinense, has cytotoxicity in androgen-dependent human prostate cancer cells. Obacunone may have the potential to prevent estrogen-responsive breast cancer through inhibition of the aromatase enzyme and inflammatory pathways, as well as activation of apoptosis.

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技术信息

生物活性

描述Obacunone belongs to a class of unique triterpenoids called limonoids, present in Citrus species. Obacunone possesses antivirulence activity and demonstrates inhibition of cell-cell signaling in Vibrio harveyi and Escherichia coli O157:H7^[3]. Obacunone inhibited SW480 cell proliferation with IC50 values of 97 μM at 24h. Sequence of events such as decreased ratio of bcl2/bax gene transcription, activation of caspase-3, fragmentation of DNA in cells treated with obacunone demonstrated induction of apoptosis by limonoids^[4]. Obacunone stimulated the transcriptional activity of the bile acids-specific G protein-coupled receptor, TGR5, in a dose-dependent manner. In addition, obacunone inhibited adipocyte differentiation in 3T3-L1 cells and antagonized ligand-stimulated peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2002 mL
- 11.0008 mL
- 22.0016 mL
- 5 mM
- 0.4400 mL
- 2.2002 mL
- 4.4003 mL
- 10 mM
- 0.2200 mL
- 1.1001 mL
- 2.2002 mL

技术信息

CAS号

751-03-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H30O7

运输

蓝冰

分子量

454.51

别名

AI3-37934;CCRIS 8657;黄柏酮

溶解度

DMSO	91.0 mg/mL (200.2 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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