|N-(2' ,4'-二氟-5-(5-(1-甲基-1H-吡唑-4-基)-1H-苯并[d]咪唑-1-基)-[1,1'-联苯]-3-基)环丙烷磺酰胺|CsnPharm

CAS No.: 1430723-35-5

ODM-203 Catalog No. CSN25230

Synonyms: ODM-203

ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The FGFR family, consisting of four highly conserved receptor tyrosine kinases (FGFR 1–4), is able to directly promote endothelial cell proliferation and tumor angiogenesis. FGFR and VEGFR signaling synergistically promote tumor angiogenesis, and activation of FGFR signaling has been described as functional compensatory angiogenic signal following development of resistance to VEGFR inhibition. ODM-203 is a novel, selective, and equipotent inhibitor of the FGFR and VEGFR families with equal potency in the low nanomolar range (IC₅₀ 6 - 35 nM). ODM-203 suppressed cell proliferation in a dose-dependent manner in H1581, SNU16, and RT4 cells with IC₅₀ values ranging from 104 nM in H1581 cells to 192 nM in RT4 cells indicating that ODM-203 can efficiently inhibit proliferation of FGFR-dependent cell lines. Moreover, ODM-203 inhibited endothelial tubule formation in a dose-dependent manner at nontoxic concentrations with an IC₅₀ value of 33 nM. In vivo, ODM-203 showed strong antitumor activity in both FGFR-dependent xenograft models and in an angiogenic xenograft model at similar well-tolerated doses. In addition, ODM-203 inhibits metastatic tumor growth in a highly angiogenesis-dependent kidney capsule syngenic model^[1].
参考文献

[1] Holmström TH, Moilanen AM, Ikonen T, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019;18(1):28-38

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9781 mL
- 9.8904 mL
- 19.7809 mL
- 5 mM
- 0.3956 mL
- 1.9781 mL
- 3.9562 mL
- 10 mM
- 0.1978 mL
- 0.9890 mL
- 1.9781 mL

技术信息

CAS号

1430723-35-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H21F2N5O2S

运输

蓝冰

分子量

505.54

别名

ODM-203

溶解度

DMSO	100.0 mg/mL (197.8 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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ODM-203 Catalog No. CSN25230

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