|(S)-5-(苄氧基)-2-(2,2-二苯乙酰基)-6-甲氧基-1,2,3,4-四氢异喹啉-3-羧酸|CsnPharm

CAS No.: 1316755-16-4

Olodanrigan Catalog No. CSN18823

Synonyms: EMA401;PD-126055;EMA-401 potasium

EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The renin-angiotensin system has physiological roles outside the cardiovascular system, including in the central and peripheral nervous systems. The angiotensin II type 2 receptor (AT2R) is a new target for neuropathic pain. EMA401, a highly selective AT2R antagonist, is under development as a novel neuropathic pain therapeutic agent^[2]. In rats, single administration of 10 mg/kg EMA401 (p.o.) resulted in a significant attenuation of theta power (0.71 ± 0.13 relative to CCI) and increase in PWL (1.26 ± 0.11 relative to CCI; n = 6 rats at d14^[3]. EMA401 (100 mg twice daily) provides superior relief of postherpetic neuralgia compared with placebo at the end of 28 days of treatment. EMA401 was well tolerated by patients^[2].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03094195	Post-herpetic Neuralgia	Phase 2	Recruiting	August 28, 2020	-
NCT02435199	Diabetic Neuropathies	Phase 2	Withdrawn	December 2016	-
NCT02426411	Neuralgia, Postherpetic	Phase 2	Withdrawn	December 2016	-

更多
参考文献

[1] Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38.
[2] Rice ASC, Dworkin RH, McCarthy TD, et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet. 2014;383(9929):1637‐1647
[3] An Electroencephalography Bioassay for Preclinical Testing of Analgesic Efficacy

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9701 mL
- 9.8507 mL
- 19.7015 mL
- 5 mM
- 0.3940 mL
- 1.9701 mL
- 3.9403 mL
- 10 mM
- 0.1970 mL
- 0.9851 mL
- 1.9701 mL

技术信息

CAS号

1316755-16-4

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C32H29NO5

运输

蓝冰

分子量

507.58

别名

EMA401;PD-126055;EMA-401 potasium

溶解度

DMSO	33.0 mg/mL (65.0 mM)
Water	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Olodanrigan Catalog No. CSN18823

靶点选择性

请登录您的专属账户

确认信息