生物活性

• 描述RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 by binding KEAP1 and inhibits the proinflammatory transcription factor NF-κB.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02255422	MItochondrial Myopathies	Phase 2	Completed	-	United States, California ... more >> UCLA Los Angeles, California, United States, 90095 United States, Massachusetts Mass General Hospital Boston, Massachusetts, United States, 02114 United States, Ohio Akron Children's Hospital Akron, Ohio, United States, 44308 United States, Pennsylvania The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15224 United States, Texas Insitute for Exercise & Environmental Medicine Dallas, Texas, United States, 75231 Baylor College of Medicine Houston, Texas, United States, 77030 University of Texas Medical School at Houston Houston, Texas, United States, 77030 Denmark Neuromuscular Clinic, Rigshospitalet, University of Copenhagen Copenhagen, Denmark, DK-2100 Collapse <<
  NCT02029716	Healthy	Phase 1	Completed	-	United States, Ohio ... more >> Medpace Clinical Pharmacology Unit Cincinnati, Ohio, United States, 45212 Collapse <<
  NCT02255435	Friedreich Ataxia	Phase 2	Active, not recruiting	December 2022	United States, California ... more >> UCLA Los Angeles, California, United States, 90095 United States, Florida University of Florida - Neurology Gainesville, Florida, United States, 32610 USF Ataxia Research Center Tampa, Florida, United States, 33612 United States, Georgia Emory University Hospital - Neurology Atlanta, Georgia, United States, 30329 United States, Iowa University of Iowa Stead Family Children's Hospital Iowa City, Iowa, United States, 52242 United States, Ohio Ohio State University - Neurology Columbus, Ohio, United States, 43221 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Australia, Victoria Murdoch Childrens Research Institute Parkville, Victoria, Australia, 3052 Austria Medical University Innsbruck Innsbruck, Austria, 6020 Italy Neurological Institute Carlo Besta Milan, Italy, 20133 United Kingdom University College of London London, United Kingdom, WC1E 6BT Collapse <<

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• 参考文献

• [1] Probst BL, Trevino I, et al. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity. PLoS One. 2015 Apr 21;10(4):e0122942.

  [2] Reisman SA, Lee CY, et al. Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis. Radiat Res. 2014 May;181(5):512-20.