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CAS No.: 1673560-66-1

PD-1-IN-17 Catalog No. CSN23861

Synonyms: CA-170;AUPM-170;PD1-IN-1. PD-L1/PD-L2/VISTA antagonist

PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM[1].

规格	价格	促销价格	库存	数量

400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述PD1-IN-1 is the closest analogue of CA170, which is a first-in-class oral small molecule in Phase 2 that directly targets both VISTA and PD-1/PD-L1 pathways. It rescued splenocyte proliferation 92% at 100nM in the presence of PD-L1.
参考文献

[1] Wang T, Wu X, et al. Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway. J Med Chem. 2019 Feb 28;62(4):1715-1730.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6713 mL
- 13.3565 mL
- 26.7130 mL
- 5 mM
- 0.5343 mL
- 2.6713 mL
- 5.3426 mL
- 10 mM
- 0.2671 mL
- 1.3356 mL
- 2.6713 mL

技术信息

CAS号

1673560-66-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H22N6O7

运输

蓝冰

分子量

374.35

别名

CA-170;AUPM-170;PD1-IN-1. PD-L1/PD-L2/VISTA antagonist

溶解度

DMSO	110.0 mg/mL (293.8 mM)
Water	100.0 mg/mL (267.1 mM)

动物实验配方

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