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CAS No.: 1255517-76-0
Synonyms: PF-04708671
PF-4708671 is an inhibitor of S6K1 (p70 ribosomal S6 kinase 1) with Ki and IC50 of 20 nM and 160 nM, respectively.
生物活性
靶点 | p70S6K IC50:160nM |
动物研究 | |
剂量 | Mice: 10 mg/kg - 100 mg/kg[2] (i.p.), 75 mg/kg (i.p.) |
给药途径 | i.p. |
实验方案
技术信息
CAS号 | 1255517-76-0 | 储存条件 |
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分子式 | C19H21F3N6 | 运输 | 蓝冰 | |||||||||||||
分子量 | 390.41 | 别名 | PF-04708671 | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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22RV1 | - | Growth Inhibition Assay | - | IC50=47.9015 μM | SANGER |
23132-87 | - | Growth Inhibition Assay | - | IC50=44.2978 μM | SANGER |
639-V | - | Growth Inhibition Assay | - | IC50=84.6129 μM | SANGER |
647-V | - | Growth Inhibition Assay | - | IC50=12.3582 μM | SANGER |
786-0 | - | Growth Inhibition Assay | - | IC50=40.9096 μM | SANGER |
8305C | - | Growth Inhibition Assay | - | IC50=52.315 μM | SANGER |
A172 | - | Growth Inhibition Assay | - | IC50=36.4187 μM | SANGER |
A2780 | - | Growth Inhibition Assay | - | IC50=13.8041 μM | SANGER |
A388 | - | Growth Inhibition Assay | - | IC50=56.0985 μM | SANGER |
A427 | - | Growth Inhibition Assay | - | IC50=5.72567 μM | SANGER |
A549 | - | Growth Inhibition Assay | - | IC50=21.8491 μM | SANGER |
ABC-1 | - | Growth Inhibition Assay | - | IC50=10.1037 μM | SANGER |
ACHN | - | Growth Inhibition Assay | - | IC50=35.1588 μM | SANGER |
AU565 | - | Growth Inhibition Assay | - | IC50=52.5509 μM | SANGER |
BB49-HNC | - | Growth Inhibition Assay | - | IC50=43.3348 μM | SANGER |
Becker | - | Growth Inhibition Assay | - | IC50=75.1105 μM | SANGER |
BEN | - | Growth Inhibition Assay | - | IC50=53.7862 μM | SANGER |
BFTC-905 | - | Growth Inhibition Assay | - | IC50=57.2898 μM | SANGER |
BHT-101 | - | Growth Inhibition Assay | - | IC50=0.82024 μM | SANGER |
BHY | - | Growth Inhibition Assay | - | IC50=79.596 μM | SANGER |
BPH-1 | - | Growth Inhibition Assay | - | IC50=55.2892 μM | SANGER |
BT-20 | - | Growth Inhibition Assay | - | IC50=76.2168 μM | SANGER |
BT-474 | - | Growth Inhibition Assay | - | IC50=22.6551 μM | SANGER |
BT-549 | - | Growth Inhibition Assay | - | IC50=85.9382 μM | SANGER |
C2BBe1 | - | Growth Inhibition Assay | - | IC50=56.2634 μM | SANGER |
C-33-A | - | Growth Inhibition Assay | - | IC50=29.2198 μM | SANGER |
C3A | - | Growth Inhibition Assay | - | IC50=18.7919 μM | SANGER |
Ca9-22 | - | Growth Inhibition Assay | - | IC50=25.6432 μM | SANGER |
CAKI-1 | - | Growth Inhibition Assay | - | IC50=64.5721 μM | SANGER |
CAL-12T | - | Growth Inhibition Assay | - | IC50=90.7895 μM | SANGER |
CAL-33 | - | Growth Inhibition Assay | - | IC50=85.6315 μM | SANGER |
CAL-51 | - | Growth Inhibition Assay | - | IC50=76.1006 μM | SANGER |
CAL-54 | - | Growth Inhibition Assay | - | IC50=52.1102 μM | SANGER |
Calu-3 | - | Growth Inhibition Assay | - | IC50=52.3733 μM | SANGER |
Calu-6 | - | Growth Inhibition Assay | - | IC50=18.1513 μM | SANGER |
CAMA-1 | - | Growth Inhibition Assay | - | IC50=55.8116 μM | SANGER |
CAPAN-1 | - | Growth Inhibition Assay | - | IC50=31.5286 μM | SANGER |
CaR-1 | - | Growth Inhibition Assay | - | IC50=52.0606 μM | SANGER |
COLO-792 | - | Growth Inhibition Assay | - | IC50=50.6237 μM | SANGER |
COLO-824 | - | Growth Inhibition Assay | - | IC50=45.8775 μM | SANGER |
COLO-829 | - | Growth Inhibition Assay | - | IC50=100.553 μM | SANGER |
COR-L105 | - | Growth Inhibition Assay | - | IC50=58.7337 μM | SANGER |
CP50-MEL-B | - | Growth Inhibition Assay | - | IC50=9.30419 μM | SANGER |
CP66-MEL | - | Growth Inhibition Assay | - | IC50=51.6408 μM | SANGER |
CW-2 | - | Growth Inhibition Assay | - | IC50=52.8654 μM | SANGER |
D-392MG | - | Growth Inhibition Assay | - | IC50=65.9434 μM | SANGER |
D-423MG | - | Growth Inhibition Assay | - | IC50=27.0715 μM | SANGER |
D-566MG | - | Growth Inhibition Assay | - | IC50=63.5224 μM | SANGER |
DJM-1 | - | Growth Inhibition Assay | - | IC50=89.8845 μM | SANGER |
DK-MG | - | Growth Inhibition Assay | - | IC50=28.7846 μM | SANGER |
DMS-114 | - | Growth Inhibition Assay | - | IC50=45.8927 μM | SANGER |
DMS-273 | - | Growth Inhibition Assay | - | IC50=44.943 μM | SANGER |
DMS-53 | - | Growth Inhibition Assay | - | IC50=44.3384 μM | SANGER |
DOK | - | Growth Inhibition Assay | - | IC50=34.6612 μM | SANGER |
DSH1 | - | Growth Inhibition Assay | - | IC50=10.8879 μM | SANGER |
EFO-27 | - | Growth Inhibition Assay | - | IC50=59.943 μM | SANGER |
ES3 | - | Growth Inhibition Assay | - | IC50=18.8364 μM | SANGER |
ES4 | - | Growth Inhibition Assay | - | IC50=64.4719 μM | SANGER |
ES7 | - | Growth Inhibition Assay | - | IC50=36.2249 μM | SANGER |
ES8 | - | Growth Inhibition Assay | - | IC50=78.0073 μM | SANGER |
EW-22 | - | Growth Inhibition Assay | - | IC50=66.395 μM | SANGER |
EW-7 | - | Growth Inhibition Assay | - | IC50=20.8588 μM | SANGER |
FADU | - | Growth Inhibition Assay | - | IC50=13.6992 μM | SANGER |
G-361 | - | Growth Inhibition Assay | - | IC50=88.1474 μM | SANGER |
G-401 | - | Growth Inhibition Assay | - | IC50=48.4415 μM | SANGER |
G-402 | - | Growth Inhibition Assay | - | IC50=40.061 μM | SANGER |
GAMG | - | Growth Inhibition Assay | - | IC50=56.5955 μM | SANGER |
GCIY | - | Growth Inhibition Assay | - | IC50=43.0803 μM | SANGER |
GCT | - | Growth Inhibition Assay | - | IC50=67.0443 μM | SANGER |
GI-ME-N | - | Growth Inhibition Assay | - | IC50=31.5353 μM | SANGER |
GT3TKB | - | Growth Inhibition Assay | - | IC50=60.6048 μM | SANGER |
HCC1419 | - | Growth Inhibition Assay | - | IC50=25.6003 μM | SANGER |
HCC1569 | - | Growth Inhibition Assay | - | IC50=24.6125 μM | SANGER |
HCC38 | - | Growth Inhibition Assay | - | IC50=61.4379 μM | SANGER |
HCT-116 | - | Growth Inhibition Assay | - | IC50=54.0327 μM | SANGER |
HGC-27 | - | Growth Inhibition Assay | - | IC50=16.1644 μM | SANGER |
HPAF-II | - | Growth Inhibition Assay | - | IC50=74.6415 μM | SANGER |
HSC-2 | - | Growth Inhibition Assay | - | IC50=19.6541 μM | SANGER |
HT-1080 | - | Growth Inhibition Assay | - | IC50=74.2574 μM | SANGER |
HT-1197 | - | Growth Inhibition Assay | - | IC50=88.1077 μM | SANGER |
HT-144 | - | Growth Inhibition Assay | - | IC50=89.5992 μM | SANGER |
HuCCT1 | - | Growth Inhibition Assay | - | IC50=57.0492 μM | SANGER |
HuH-7 | - | Growth Inhibition Assay | - | IC50=69.1002 μM | SANGER |
HuO9 | - | Growth Inhibition Assay | - | IC50=76.0048 μM | SANGER |
HuP-T3 | - | Growth Inhibition Assay | - | IC50=96.1004 μM | SANGER |
HUTU-80 | - | Growth Inhibition Assay | - | IC50=18.3959 μM | SANGER |
IA-LM | - | Growth Inhibition Assay | - | IC50=80.3511 μM | SANGER |
IGROV-1 | - | Growth Inhibition Assay | - | IC50=78.555 μM | SANGER |
IST-MES1 | - | Growth Inhibition Assay | - | IC50=18.6508 μM | SANGER |
IST-SL1 | - | Growth Inhibition Assay | - | IC50=71.2324 μM | SANGER |
JAR | - | Growth Inhibition Assay | - | IC50=65.5516 μM | SANGER |
K5 | - | Growth Inhibition Assay | - | IC50=41.3686 μM | SANGER |
KGN | - | Growth Inhibition Assay | - | IC50=25.7547 μM | SANGER |
KLE | - | Growth Inhibition Assay | - | IC50=33.4334 μM | SANGER |
KNS-62 | - | Growth Inhibition Assay | - | IC50=50.7508 μM | SANGER |
KNS-81-FD | - | Growth Inhibition Assay | - | IC50=33.5008 μM | SANGER |
KP-4 | - | Growth Inhibition Assay | - | IC50=38.4739 μM | SANGER |
KU-19-19 | - | Growth Inhibition Assay | - | IC50=28.995 μM | SANGER |
KYSE-150 | - | Growth Inhibition Assay | - | IC50=73.6118 μM | SANGER |
KYSE-520 | - | Growth Inhibition Assay | - | IC50=35.2361 μM | SANGER |
LB1047-RCC | - | Growth Inhibition Assay | - | IC50=76.7619 μM | SANGER |
LB2241-RCC | - | Growth Inhibition Assay | - | IC50=12.5779 μM | SANGER |
LB373-MEL-D | - | Growth Inhibition Assay | - | IC50=26.1938 μM | SANGER |
LB831-BLC | - | Growth Inhibition Assay | - | IC50=76.3217 μM | SANGER |
LB996-RCC | - | Growth Inhibition Assay | - | IC50=58.0287 μM | SANGER |
LK-2 | - | Growth Inhibition Assay | - | IC50=72.8612 μM | SANGER |
LN-405 | - | Growth Inhibition Assay | - | IC50=20.8965 μM | SANGER |
LNCaP-Clone-FGC | - | Growth Inhibition Assay | - | IC50=31.4921 μM | SANGER |
LS-123 | - | Growth Inhibition Assay | - | IC50=57.5668 μM | SANGER |
LS-411N | - | Growth Inhibition Assay | - | IC50=89.3388 μM | SANGER |
LXF-289 | - | Growth Inhibition Assay | - | IC50=38.0047 μM | SANGER |
MCF7 | - | Growth Inhibition Assay | - | IC50=83.2897 μM | SANGER |
MC-IXC | - | Growth Inhibition Assay | - | IC50=100.615 μM | SANGER |
MDA-MB-175-VII | - | Growth Inhibition Assay | - | IC50=25.2517 μM | SANGER |
MDA-MB-453 | - | Growth Inhibition Assay | - | IC50=12.1603 μM | SANGER |
MEL-JUSO | - | Growth Inhibition Assay | - | IC50=24.6908 μM | SANGER |
MES-SA | - | Growth Inhibition Assay | - | IC50=59.4509 μM | SANGER |
MG-63 | - | Growth Inhibition Assay | - | IC50=30.5994 μM | SANGER |
MKN28 | - | Growth Inhibition Assay | - | IC50=56.8013 μM | SANGER |
MKN45 | - | Growth Inhibition Assay | - | IC50=80.3174 μM | SANGER |
MKN7 | - | Growth Inhibition Assay | - | IC50=91.3551 μM | SANGER |
MLMA | - | Growth Inhibition Assay | - | IC50=61.6163 μM | SANGER |
MMAC-SF | - | Growth Inhibition Assay | - | IC50=17.3727 μM | SANGER |
NB5 | - | Growth Inhibition Assay | - | IC50=51.4509 μM | SANGER |
NB69 | - | Growth Inhibition Assay | - | IC50=23.152 μM | SANGER |
NB7 | - | Growth Inhibition Assay | - | IC50=24.188 μM | SANGER |
NCI-H1048 | - | Growth Inhibition Assay | - | IC50=58.2188 μM | SANGER |
NCI-H1355 | - | Growth Inhibition Assay | - | IC50=46.618 μM | SANGER |
NCI-H1437 | - | Growth Inhibition Assay | - | IC50=74.6326 μM | SANGER |
NCI-H1623 | - | Growth Inhibition Assay | - | IC50=28.8342 μM | SANGER |
NCI-H1651 | - | Growth Inhibition Assay | - | IC50=10.0276 μM | SANGER |
NCI-H1693 | - | Growth Inhibition Assay | - | IC50=54.2103 μM | SANGER |
NCI-H1755 | - | Growth Inhibition Assay | - | IC50=26.8841 μM | SANGER |
NCI-H1793 | - | Growth Inhibition Assay | - | IC50=14.4085 μM | SANGER |
NCI-H1975 | - | Growth Inhibition Assay | - | IC50=53.8966 μM | SANGER |
NCI-H1993 | - | Growth Inhibition Assay | - | IC50=75.7397 μM | SANGER |
NCI-H2030 | - | Growth Inhibition Assay | - | IC50=47.8906 μM | SANGER |
NCI-H2170 | - | Growth Inhibition Assay | - | IC50=47.7584 μM | SANGER |
NCI-H226 | - | Growth Inhibition Assay | - | IC50=78.1315 μM | SANGER |
NCI-H2291 | - | Growth Inhibition Assay | - | IC50=81.6842 μM | SANGER |
NCI-H2342 | - | Growth Inhibition Assay | - | IC50=12.3995 μM | SANGER |
NCI-H2347 | - | Growth Inhibition Assay | - | IC50=98.1042 μM | SANGER |
NCI-H2405 | - | Growth Inhibition Assay | - | IC50=85.2997 μM | SANGER |
NCI-H28 | - | Growth Inhibition Assay | - | IC50=35.6695 μM | SANGER |
NCI-H460 | - | Growth Inhibition Assay | - | IC50=65.0897 μM | SANGER |
NCI-H661 | - | Growth Inhibition Assay | - | IC50=13.6449 μM | SANGER |
NOS-1 | - | Growth Inhibition Assay | - | IC50=67.6867 μM | SANGER |
NUGC-3 | - | Growth Inhibition Assay | - | IC50=70.9644 μM | SANGER |
OAW-28 | - | Growth Inhibition Assay | - | IC50=64.9647 μM | SANGER |
OC-314 | - | Growth Inhibition Assay | - | IC50=47.8478 μM | SANGER |
OCUB-M | - | Growth Inhibition Assay | - | IC50=6.66102 μM | SANGER |
OE19 | - | Growth Inhibition Assay | - | IC50=10.1733 μM | SANGER |
ONS-76 | - | Growth Inhibition Assay | - | IC50=44.7661 μM | SANGER |
OVCAR-4 | - | Growth Inhibition Assay | - | IC50=41.7568 μM | SANGER |
OVCAR-8 | - | Growth Inhibition Assay | - | IC50=59.1716 μM | SANGER |
PANC-10-05 | - | Growth Inhibition Assay | - | IC50=75.2865 μM | SANGER |
RERF-LC-MS | - | Growth Inhibition Assay | - | IC50=32.6747 μM | SANGER |
RH-1 | - | Growth Inhibition Assay | - | IC50=68.5559 μM | SANGER |
RH-18 | - | Growth Inhibition Assay | - | IC50=46.3733 μM | SANGER |
RMG-I | - | Growth Inhibition Assay | - | IC50=22.2668 μM | SANGER |
RT4 | - | Growth Inhibition Assay | - | IC50=85.2403 μM | SANGER |
S-117 | - | Growth Inhibition Assay | - | IC50=75.755 μM | SANGER |
SAS | - | Growth Inhibition Assay | - | IC50=18.6455 μM | SANGER |
SBC-5 | - | Growth Inhibition Assay | - | IC50=35.5116 μM | SANGER |
SCC-4 | - | Growth Inhibition Assay | - | IC50=30.3354 μM | SANGER |
SCC-9 | - | Growth Inhibition Assay | - | IC50=59.4753 μM | SANGER |
SF295 | - | Growth Inhibition Assay | - | IC50=63.6655 μM | SANGER |
SH-4 | - | Growth Inhibition Assay | - | IC50=54.138 μM | SANGER |
SHP-77 | - | Growth Inhibition Assay | - | IC50=72.119 μM | SANGER |
SKG-IIIa | - | Growth Inhibition Assay | - | IC50=75.3341 μM | SANGER |
SK-LMS-1 | - | Growth Inhibition Assay | - | IC50=9.01302 μM | SANGER |
SK-MG-1 | - | Growth Inhibition Assay | - | IC50=96.1348 μM | SANGER |
SK-N-DZ | - | Growth Inhibition Assay | - | IC50=41.3823 μM | SANGER |
SK-N-FI | - | Growth Inhibition Assay | - | IC50=59.3207 μM | SANGER |
SNU-449 | - | Growth Inhibition Assay | - | IC50=65.7616 μM | SANGER |
SNU-C2B | - | Growth Inhibition Assay | - | IC50=43.6436 μM | SANGER |
SW1116 | - | Growth Inhibition Assay | - | IC50=72.1407 μM | SANGER |
SW13 | - | Growth Inhibition Assay | - | IC50=11.9319 μM | SANGER |
SW1573 | - | Growth Inhibition Assay | - | IC50=50.2435 μM | SANGER |
SW684 | - | Growth Inhibition Assay | - | IC50=7.52268 μM | SANGER |
SW872 | - | Growth Inhibition Assay | - | IC50=100.456 μM | SANGER |
T47D | - | Growth Inhibition Assay | - | IC50=20.1485 μM | SANGER |
T84 | - | Growth Inhibition Assay | - | IC50=42.1263 μM | SANGER |
TE-1 | - | Growth Inhibition Assay | - | IC50=39.6589 μM | SANGER |
TE-6 | - | Growth Inhibition Assay | - | IC50=43.8894 μM | SANGER |
TE-8 | - | Growth Inhibition Assay | - | IC50=15.3465 μM | SANGER |
TYK-nu | - | Growth Inhibition Assay | - | IC50=75.3102 μM | SANGER |
U031 | - | Growth Inhibition Assay | - | IC50=21.4802 μM | SANGER |
U251 | - | Growth Inhibition Assay | - | IC50=73.8168 μM | SANGER |
U-2-OS | - | Growth Inhibition Assay | - | IC50=73.1828 μM | SANGER |
UACC-257 | - | Growth Inhibition Assay | - | IC50=13.4453 μM | SANGER |
UACC-893 | - | Growth Inhibition Assay | - | IC50=5.19886 μM | SANGER |
UMC-11 | - | Growth Inhibition Assay | - | IC50=78.0884 μM | SANGER |
UM-UC-3 | - | Growth Inhibition Assay | - | IC50=37.8746 μM | SANGER |
VA-ES-BJ | - | Growth Inhibition Assay | - | IC50=56.8745 μM | SANGER |
VMRC-RCZ | - | Growth Inhibition Assay | - | IC50=81.4425 μM | SANGER |
WM-115 | - | Growth Inhibition Assay | - | IC50=81.4114 μM | SANGER |
YAPC | - | Growth Inhibition Assay | - | IC50=49.8073 μM | SANGER |
YKG-1 | - | Growth Inhibition Assay | - | IC50=46.0355 μM | SANGER |
靶点 | Description | IC50 |
---|---|---|
p70S6K | IC50:160nM |
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