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CAS No.: 50-33-9

Phenylbutazone/保泰松 Catalog No. CSN17306

Synonyms: Butazolidine;Fenilbutazona;Diphenylbutazone

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.

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实验方案

技术信息

生物活性

描述Phenylbutazone (PB), a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Prostacyclin synthase is even more sensitive to inactivation by the combined PB and H2O2 treatment, with a corresponding half-maximal effect at PB concentrations near 25 mM^[3]. However at IC80, phenylbutazone (+134.4%) and flunixin (+29.7%) had greater COX-2 selectivity than at IC50^[4]. Phenylbutazone acts by inhibiting the cyclooxygenase enzyme system, which is responsible for synthesis of prostanoids such as PGE2. It markedly reduces prostanoid-dependent swelling, edema, erythema, and hypersensitivity to pain in inflamed tissues. Phenylbutazone is highly bound (greater than 98%) to plasma protein. After i.v. injection, blood levels decline with an elimination half-life of 3-10 h. The plasma kinetics of phenylbutazone may be dose dependent, with the plasma half-life increasing as the drug dosage level increases. Plasma residues of the drug at 24 h after a single i.v. dose of 2g/450 kg average about 0.9 mg/ml, but considerable variation occurs. Under optimal conditions, the bioavailability of oral phenylbutazone is probably in the region of 70%^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2429 mL
- 16.2143 mL
- 32.4286 mL
- 5 mM
- 0.6486 mL
- 3.2429 mL
- 6.4857 mL
- 10 mM
- 0.3243 mL
- 1.6214 mL
- 3.2429 mL

技术信息

CAS号

50-33-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H20N2O2

运输

蓝冰

分子量

308.37

别名

Butazolidine;Fenilbutazona;Diphenylbutazone;Butapyrazole;Phenylbutazonum;Butadione;Butapirazol;Butazolidin;Fenilbutazon;保泰松

溶解度

DMSO	60.0 mg/mL (194.6 mM)
Water	Insoluble
Ethanol	60.0 mg/mL (194.6 mM)

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