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CAS No.: 477-47-4
Synonyms: AXL1717;PPP;Picropodophyllotoxin
Picropodophyllotoxin is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM, and exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II.
生物活性
靶点 | IGF-1R IC50:1nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01466647 | Non Small Cell Lung Cancer | Phase 1 | Completed | - | Sweden ... more >> KFUE Uppsala, Sweden University Hospital Uppsala, Sweden Collapse << |
NCT01725555 | Solid Tumors ... more >>Hematological Malignancies Collapse << | Phase 1 | Completed | - | Sweden ... more >> KFUE Uppsala, Sweden Collapse << |
NCT01062620 | Solid Tumors | Phase 1 | Completed | - | Sweden ... more >> Uppsala University Hospital Uppsala, Sweden, SE-75185 Collapse << |
实验方案
技术信息
CAS号 | 477-47-4 | 储存条件 |
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分子式 | C22H22O8 | 运输 | 蓝冰 | |||||||
分子量 | 414.41 | 别名 | AXL1717;PPP;Picropodophyllotoxin;NSC 36407;picropodophyllin;苦鬼臼毒素;鬼臼苦素 | |||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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A-549 (human lung carcinoma) neoplastic cell line | - | Cytotoxic assay | - | In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line, IC50=60 nM | 14980682 |
HT-29 (human colon carcinoma) neoplastic cell line | - | Cytotoxic assay | - | In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line, IC50=60 nM | 14980682 |
P-388 neoplastic cell line | - | Cytotoxic assay | - | In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line, IC50=60 nM | 14980682 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01466647 | Non Small Cell Lung Cancer | Phase 1 | Completed | - | Sweden ... more >> KFUE Uppsala, Sweden University Hospital Uppsala, Sweden Collapse << |
NCT01725555 | Solid Tumors ... more >>Hematological Malignancies Collapse << | Phase 1 | Completed | - | Sweden ... more >> KFUE Uppsala, Sweden Collapse << |
NCT01062620 | Solid Tumors | Phase 1 | Completed | - | Sweden ... more >> Uppsala University Hospital Uppsala, Sweden, SE-75185 Collapse << |
NCT01561456 | Non-small-cell Lung Cancer ... more >> Squamous Cell Carcinoma Adenocarcinoma of the Lung Collapse << | Phase 2 | Completed | - | Belarus ... more >> State Medical Institution: Republic Scientific Oncology Center Poselok, Minsk Region, Belarus, 223040 Gomel Regional Clinical Oncology Center Gomel, Belarus, 246012 Minsk City Clinical Oncology Center Minsk, Belarus, 220013 Vitebsk Regional Clinical Oncology Center Vitebsk, Belarus, 210603 Hungary Semmelweis University; Clinic for Pulmonology Budapest, Hungary, 1125 University of Debrecen Medical and Health Science Center, Clinic of Pulmonology Debrecen, Hungary, 4042 Kenezy Gyula County Hospital Debrecen, Hungary, 4043 Hospital for Thoracic Diseases of Csongrad County Local Government Deszk, Hungary, 6772 Poland Wladyslaw Bieganski Regional Specialist Hospital Grudziadz, Poland, 86-300 Maria Sklodowska-Curie Institute of Oncology in Warsaw Warsaw, Poland, 02781 Russian Federation State Therapeutical and Prophylactic Institution: Chelyabinsk Regional Oncology Center Chelyabinsk, Russian Federation, 454087 Sverdlovsk Regional Oncology Center Ekaterinburg, Russian Federation, 620036 City Clinical Hospital #1 Novosibirsk, Russian Federation, 630047 Orel Oncology Center Orel, Russian Federation, 302020 State Higher Educational Institution St. Petersburg State Medical University n. a. after I. P. Pavlov under Federal Agency for Healthcare and Social Development, Research Institute of Pulmonology Saint Petersburg, Russian Federation, 197089 St. Petersburg State Medical Institution Municipal Clinical Oncology Center St. Petersburg, Russian Federation, 197022 Tula Regional Oncology Center Tula, Russian Federation, 300053 Ukraine Dnipropetrovsk City Multispecialty Clinical Hospital #4 Dniepropetrovsk, Ukraine, 49102 Public Clinical Treatment and Prophylaxis Institution: Donetsk Regional Antitumor Center Donetsk, Ukraine, 83092 Kharkiv, State Institution: S.P. Hryhoriev Institute of Medical Radiology under the Ukrainian Academy of Medical Sciences Kharkiv, Ukraine, 61024 Public Healthcare Institution: Kharkiv Regional Clinical Oncology Center Kharkiv, Ukraine, 61070 Kyiv City Oncology Hospital Kyiv, Ukraine, 03115 Lviv State Regional Treatment and Diagnostics Oncology Center Lviv, Ukraine, 79031 Zakarpattia Regional Clinical Oncology Center Uzhhorod, Ukraine, 88014 Collapse << |
NCT01721577 | Glioblastoma ... more >>Gliosarcoma Anaplastic Astrocytoma Anaplastic Oligodendroglioma Anaplastic Oligoastrocytoma Anaplastic Ependymoma Collapse << | Phase 1 Phase 2 | Unknown | December 2015 | United States, Illinois ... more >> Rush University Medical Center Recruiting Chicago, Illinois, United States, 60612 Contact: Jeanne Sixta, RN 312-942-2388 jeanne_sixta@rush.edu Principal Investigator: Robert Aiken, MD Collapse << |
靶点 | Description | IC50 |
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IGF-1R | IC50:1nM |
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