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CAS No.: 2101700-15-4
Synonyms: LOXO-305;LY-3527727
Pirtobrutinib is a highly selective and non-covalent BTK inhibitor, which may be regarded as a third generation BTK inhibitor. It potently inhibited the cellular activity (measured by Y223 autophosphorylation) of BTK C481S, T and R mutations and displayed strong equilibrium binding to WT BTK and several BTK C481 substitution mutations. It may overcome acquired resistance to covalent BTK inhibitors in patients without significant off-target toxicity.
生物活性
实验方案
技术信息
CAS号 | 2101700-15-4 | 储存条件 |
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分子式 | C22H21F4N5O3 | 运输 | 蓝冰 | |
分子量 | 479.43 | 别名 | LOXO-305;LY-3527727 |
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