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CAS No.: 72702-95-5

Ponalrestat Catalog No. CSN27705

Synonyms: ICI 128436;ICI-128,436;Statil

Statil is a selective and noncompetitive aldose reductase 2 inhibitor with Ki value of 7.7nM.

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技术信息

生物活性

描述Aldose reductase 2 (ALR2), catalysing reduction of glucose to sorbitol, is strongly associated with pathogenesis of some of the symptoms of diabetes. Statil is an orally active, selective and noncompetitive ALR with K_is of 7.7 nM and 60 nM for ALR2 and ALR1, respectively^[1]. In vitro, Statil (1, 10, 100 μM; 6 h) reduced PGF2α production in response to IL-1 in both cultured endometrial cells and endometrial explants^[2]. In vivo, Statil (10 or 50 mg/kg; 8 weeks) reduced sorbitol accumulation in rats indicating efficacy of aldose reductase inhibition^[3].
参考文献

[1] Ward WH, et al. Ponalrestat: a potent and specific inhibitor of aldose reductase. Biochem Pharmacol. 1990 Jan 15;39(2):337-46
[2] Bresson E, et al. The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium. J Clin Endocrinol Metab. 2011 Jan;96(1):210-9
[3] Calcutt NA, et al. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr;47(4):718-24

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5563 mL
- 12.7815 mL
- 25.5629 mL
- 5 mM
- 0.5113 mL
- 2.5563 mL
- 5.1126 mL
- 10 mM
- 0.2556 mL
- 1.2781 mL
- 2.5563 mL

技术信息

CAS号

72702-95-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H12BrFN2O3

运输

蓝冰

分子量

391.19

别名

ICI 128436;ICI-128,436;Statil;MK-538;MK538. Brand name: Statil;Statyl

溶解度

DMSO	60.0 mg/mL (153.4 mM) warming

动物实验配方

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